■2019年冠状病毒病(COVID-19)永久改变了世界。尽管已经流行了将近3年,这种疾病的中长期并发症,包括内分泌失调,仍然不清楚。我们的研究旨在评估首次感染后6个月COVID-19对内分泌系统的持续影响。
我们将接受COVID-19的患者与大流行前进行的基于人群的研究中年龄和性别匹配的受试者进行了比较。我们评估了与代谢和内分泌系统相关的多个参数的差异,包括空腹血糖,胰岛素,脂质,身体成分,促甲状腺激素(TSH),游离甲状腺素(fT4),游离三碘甲状腺原氨酸(fT3),抗甲状腺球蛋白(aTG)和抗甲状腺过氧化物酶(aTPO)抗体,催乳素,皮质醇,睾丸激素,和雌二醇。
■我们发现fT3和fT4水平显着降低,并伴有较高水平的TSH和aTPO抗体,在COVID-19幸存者中。此外,我们发现,与对照组相比,SARS-CoV2感染患者的催乳素水平较高,睾酮水平较低.有趣的是,仅在男性受试者中观察到睾酮水平的差异.我们没有检测到病例和对照组之间的身体成分或代谢和血糖参数的显著差异。除了COVID-19幸存者的HOMA2-B指数值明显更高。
■我们的研究表明,严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)感染可能会对内分泌系统产生长期影响,包括甲状腺功能受到抑制,催乳素,和男性性激素分泌。此外,我们发现在6个月的随访中,COVID-19对血糖参数没有影响,脂质分布,肝功能,身体成分,皮质醇水平,和雌二醇水平。
Coronavirus disease 2019 (COVID-19) has permanently changed the world. Despite having been a pandemic for nearly 3 years, the mid- and long-term complications of this disease, including endocrine disorders, remain unclear. Our study aimed to evaluate the lasting effects of COVID-19 on the endocrine system 6 months after initial infection.
We compared patients who underwent COVID-19 to age- and sex-matched subjects from a population-based study conducted before the pandemic. We evaluated differences in multiple parameters related to metabolism and the endocrine system including fasting glucose, insulin, lipids, body composition, thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), anti-thyroglobulin (aTG) and anti-thyroid peroxidase (aTPO) antibodies, prolactin, cortisol, testosterone, and estradiol.
We found significantly lower levels of fT3 and fT4, accompanied by higher levels of TSH and aTPO antibodies, in COVID-19 survivors. Moreover, we found that patients who underwent SARS-CoV2 infection had higher levels of prolactin and lower levels of testosterone than controls. Interestingly, differences in testosterone levels were observed only in male subjects. We did not detect significant differences in body composition or metabolic and glycemic parameters between cases and controls, except for significantly higher values of the HOMA2-B index in COVID-19 survivors.
Our study indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection might have long-term consequences on the endocrine system, including the suppressed function of the thyroid gland, prolactin, and male sex hormone secretion. Moreover, we showed that in a 6-month follow-up, COVID-19 had no consequences on glycemic parameters, lipid profiles, liver function, body composition, cortisol levels, and estradiol levels.