■心内膜弹性纤维增生症的特征是心内膜内弹性纤维和胶原纤维的增殖,引起弥漫性或局部增厚。一名四个半月大的婴儿住进了当地医院,有一天的癫痫病史.婴儿出现心力衰竭特征,入院后一周内死亡。在验尸时,发现心脏因心室扩张而增大。左心室内膜明显增厚,外观呈白色。组织病理学显示心内膜有一层厚厚的胶原纤维组织,马森三色染色证实了这一点。死亡原因为心内膜弹性纤维增生引起的扩张型心肌病。心肌纤维化的潜在机制尚不清楚。假设遗传,传染性,炎症,和营养过程参与这种情况。该病例强调了大体标本检查和特殊染色方法的重要性,以支持死后检查后的组织病理学。确定死因。
UNASSIGNED: Endocardial fibroelastosis is characterized by proliferation of both elastic and collagenous fibers within the
endocardium, causing diffuse or localized thickening. A four-and-a-half-month-old baby was admitted to a local hospital, with a history of seizures for one day. Baby developed features of heart failure and died within one week after admission. At the post-mortem examination, heart was found to be enlarged with dilated ventricles. The
endocardium of left ventricle was markedly thickened with a whitish appearance. Histopathology showed a thick layer of collagenous fibrous tissue in the
endocardium, which was confirmed by Masson trichrome stain. The cause of death was offered as dilated cardiomyopathy due to endocardial fibroelastosis. The underlying mechanisms of myocardial fibrosis remain unclear. It is hypothesized that genetic, infectious, inflammatory, and nutritional processes are involved in this condition. This
case highlights the importance of gross specimen examination and special staining methods to support histopathology after postmortem examination, for ascertaining the cause of death.