The business case for employee retention is well established in the literature. Simply stated, it is more financially advantageous to keep employees than to recruit and hire someone new. Recent studies have estimated the cost of turnover due to physician burnout in the United States at approximately $4.3 billion annually. The question remains, What are the best strategies to retain employees and keep them engaged? This article addresses the critical issues of employee turnover, delineates the reasons that employees leave, characterizes employees at risk of turnover, and describes retention strategies that overlap with strategies that address burnout and disengagement.