Elbow Joint

弯头接头
  • 文章类型: Journal Article
    方法:我们介绍了一例II型(骨内)正中神经卡压的患者,该患者是根据临床检查和磁共振成像诊断的,并接受了内侧上髁截骨术治疗,神经溶解,并在受伤后一个月内将神经移位到其解剖位置。我们的患者在5个月时完全恢复了运动和感觉,具有完整的功能和握力。
    结论:肘关节后外侧脱位后正中神经卡压是一种罕见的并发症,文献报道约40例。此病例说明了及时诊断和治疗的重要性。
    METHODS: We present a case of type II (intraosseous) entrapment of the median nerve in a patient who was diagnosed based on clinical examination and magnetic resonance imaging and who was treated with medial epicondyle osteotomy, neurolysis, and transposition of the nerve to its anatomical position within a month of injury. Our patient made a complete motor and sensory recovery at 5 months with complete functionality and grip strength.
    CONCLUSIONS: Median nerve entrapment after posterolateral elbow dislocation is a rare complication with roughly 40 cases reported in the literature. This case illustrates the importance of prompt diagnosis and treatment.
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  • 文章类型: Journal Article
    背景:上肢问题对导致疼痛和关节活动受限的全球人口产生重大影响,最终影响他们的生活质量。传统治疗,如非甾体抗炎药和皮质类固醇,通常会带来不良的副作用,促使患者寻求替代疗法。在这次审判中,我们假设舒缓乳膏凝胶(SCG)将改善肩部和肘部的活动范围和慢性疼痛.该试验的目的是评估SCG在改善肩部和肘部的活动范围和慢性疼痛方面的功效。
    方法:双盲,随机化,进行安慰剂对照试验以比较SCG和安慰剂凝胶的效果.SCG含有葡萄精华,千层紫千层精油,etc,并根据良好生产规范标准制造。安慰剂凝胶将以类似的外观进行处理,质地和气味,但缺乏活性成分。将从四个研究地点招募70名上肢问题参与者,包括香港中文大学的临床中心和体育系。参与者将被随机分配到治疗组或安慰剂组2周。主要结果是上肢的活动范围,由测角器评估,测量肩膀的主动屈曲和外展,和积极的屈伸的肘部。主要疗效分析将基于遵循意向治疗原则的完整分析集。
    背景:试验已获得中大-新界东联组(CRE-2023.142)的批准,患者登记于2023年7月开始.在参与之前,将获得所有参与者的书面知情同意书。研究结果将通过发表在同行评审的期刊和会议上的演讲来传播。
    背景:NCT05799391。
    BACKGROUND: Upper limb problems have a significant impact on the global population leading to pain and restricted joint mobility, ultimately impacting their quality of life. Traditional treatments, such as non-steroidal anti-inflammatory drugs and corticosteroids, often come with undesirable side effects, prompting patients to seek alternative therapies. In this trial, we hypothesise that soothing cream gel (SCG) will improve range of motion and chronic pain in the shoulder and elbow. The objective of this trial is to evaluate the efficacy of SCG in improving the range of motion and chronic pain in the shoulder and elbow.
    METHODS: A double-blinded, randomised, placebo-controlled trial is conducted to compare the effects of SCG and placebo gel. SCG contains Vitis vinifera essence, Melaleuca viridiflora essential oil, etc, and is manufactured according to Good Manufacturing Practice standards. The placebo gel will be processed with similar appearance, texture and scent but will lack active ingredients. 70 participants with upper limb problems will be recruited from four study sites, including clinical centres and a sport department at the Chinese University of Hong Kong (CUHK). Participants will be randomly assigned to either treatment group or placebo group for 2 weeks. Primary outcome will be the range of motion in the upper limb, assessed by a goniometer, to measure active flexion and abduction for the shoulder, and active flexion and extension for the elbow. The primary efficacy analyses will be based on the full analysis set following the intention-to-treat principle.
    BACKGROUND: The trial has obtained approval from the joint CUHK-New Territories East Cluster (CRE-2023.142), and the patient enrolment commenced in July 2023. Written informed consent will be obtained from all participants prior to participation. Study results will be disseminated through publication in peer-reviewed journals and presentations at conference.
    BACKGROUND: NCT05799391.
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  • 文章类型: Journal Article
    背景:肱骨干骨折是上肢的常见损伤,主要的手术治疗方式是锁定加压钢板(LCP)技术。前内侧微创接骨板(MIPO)技术的出现使其在临床实践中逐步实施。然而,MIPO的疗效和长期结果需要进一步调查。本研究的目的是比较LCP和MIPO在肱骨干骨折治疗中的疗效。
    方法:本研究对2016年6月至2019年12月诊断为肱骨干骨折的患者进行了回顾性分析。根据手术方式的不同将患者分为MIPO组和LCP组。该研究分析了住院时间,辐射暴露,手术时间,和术后手臂的残疾,肩和手(DASH)得分使用统计方法。
    结果:共有53名符合纳入标准的患者被纳入研究。与LCP组相比,MIPO组的住院时间显着减少(住院时间:5.39±2.23天vs12.00±7.19天,P<0.001)。所有患者均在手术后形成骨痂。然而,MIPO组的辐射暴露量明显高于LCP组(45.96±19.49vs5.33±2.20,P<0.001)。此外,从入院到手术的时间没有统计学上的显着差异,手术时间,两组之间的愈合时间(从入院到手术时间:P=0.593;手术时间:P=0.407;愈合时间:P=0.664)。术后随访期间,与LCP组相比,MIPO组的6周和3个月DASH得分显着降低(6周:34.17±12.16vs45.65±22.94,P=0.028;3个月:17.43±11.70vs30.12±9.80,P<0.001)。然而,两组6个月和12个月的DASH评分差异无统计学意义(6个月:P=0.787;12个月:P=0.058)。
    结论:与LCP技术相比,MIPO技术在治疗肱骨干骨折方面提供了更好的肩肘短期功能恢复,同时确保等效的手术愈合。
    BACKGROUND: Humeral shaft fractures are a common injury of the upper limb, with the primary surgical treatment modality being the locking compression plate (LCP) technique. The advent of Anterior medial minimally invasive plate osteosynthesis (MIPO) technology has led to its gradual implementation in clinical practice. However, the efficacy and long-term outcomes of MIPO require further investigation. The objective of this study is to compare the therapeutic effects of LCP and MIPO in the management of humeral shaft fractures.
    METHODS: The present study conducted a retrospective review of patients diagnosed with humeral shaft fractures between June 2016 and December 2019. The patients were divided into MIPO and LCP groups based on the different surgical methods. The study analyzed the length of hospital stay, radiation exposure, operative time, and postoperative Disabilities of the Arm, Shoulder and Hand (DASH) scores using statistical methods.
    RESULTS: A total of 53 patients who met the inclusion criteria were included in the study. The MIPO group demonstrated a statistically significant reduction in length of hospital stay compared to the LCP group (length of hospital stay: 5.39 ± 2.23 days vs 12.00 ± 7.19 days, P < 0.001). All patients achieved callus formation after surgery. However, the MIPO group had significantly more radiation exposures than the LCP group (45.96 ± 19.49 vs 5.33 ± 2.20, P < 0.001). Additionally, there was no statistically significant difference observed in the time from admission to surgery, operative time,and healing time between the two groups (the time from admission to surgery: P = 0.593; operative time: P = 0.407; Healing time: P = 0.664). During the postoperative follow-up, the MIPO group exhibited significantly lower 6-week and 3-month DASH scores compared to the LCP group (6-week: 34.17 ± 12.16 vs 45.65 ± 22.94, P = 0.028; 3-month: 17.43 ± 11.70 vs 30.12 ± 9.80, P < 0.001). However, there was no statistically significant difference in the 6-month and 12-month DASH scores between the two groups (6-month: P = 0.787; 12-month: P = 0.058).
    CONCLUSIONS: The MIPO technique provides better short-term functional recovery of the shoulder and elbow compared to the LCP technique in the treatment of humeral shaft fractures, while ensuring equivalent surgical healing.
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  • 文章类型: Journal Article
    背景:创伤性肘脱位是攀岩运动中最常见的损伤之一。由于典型的低高度向后落入碰撞垫,它们最常见于抱石(通常在室内进行的具有强烈上升趋势的攀爬学科)。仍然没有关于这种典型的抱石伤的功能结果和恢复运动的数据。
    方法:在我们的I级创伤中心对2011年至2020年间所有因抱石相关跌倒导致的肘关节脱位的患者进行了回顾性分析。创伤机制,获得了损伤类型和治疗方法。随访是通过在线问卷进行的,包括与运动相关的影响,回到运动和肘部自我评估评分(ESAS)。
    结果:确定了30例抱石事故后肘关节脱位的患者。在22例(73.3%)患者中,损伤是简单的脱位。问卷由20名患者完成。主要机制是低高度掉入碰撞垫。每2例患者进行外科手术。18名患者(90%)报告在4.7±2.1个月后恢复了抱石。12例患者(66.7%)恢复了受伤前的水平。中期/长期随访(平均105±37.5个月)显示ESAS评分(97.2±3.9分)的优异结果。只有3名患者(15%)报告了持续有限的运动范围或不稳定。
    结论:大多数运动员能够恢复抱石运动,但在这项要求苛刻的上肢运动中,只有三分之二的运动员恢复了受伤前的表现水平。独特的低身高创伤机制可能会产生虚假的安全感。应该为攀岩运动员设置特定的意识和安全特征,以减少肘部受伤。
    BACKGROUND: Traumatic elbow dislocations are among the most common injuries in sport climbing. They occur most frequently in bouldering (a climbing discipline with strong upward trend often performed indoors) due to the typical low-height backward fall into crashpads. There is still no data about the functional outcome and return to sport of this typical bouldering injury.
    METHODS: All Patients with elbow dislocations due to a bouldering associated fall between 2011 and 2020 were identified retrospectively in our level I trauma centre. Trauma mechanisms, injury types and therapies were obtained. Follow-up was performed with an online questionnaire including sports-related effects, return to sport and the Elbow Self-Assessment Score (ESAS).
    RESULTS: 30 patients with elbow dislocations after bouldering accidents were identified. In 22 (73.3%) patients the injury was a simple dislocation. The questionnaire was completed by 20 patients. The leading mechanism was a low-height fall into crashpads. Surgical procedures were performed in every second patient. 18 patients (90%) reported return to bouldering after 4.7 ± 2.1 months. 12 patients (66.7%) regained their pre-injury level. Mid-/Long-term follow-up (mean 105 ± 37.5 months) showed excellent results in ESAS score (97.2 ± 3.9 points). Persistent limited range of motion or instability was reported by only 3 patients (15%).
    CONCLUSIONS: Most athletes are able to return to bouldering but only two thirds regain their pre-injury performance level in this demanding upper-extremity sport. The unique low-height trauma mechanism may create a false sense of security. Specific awareness and safety features should be placed for climbing athletes to reduce elbow injuries.
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  • 文章类型: Journal Article
    目的:目前已有许多治疗尺骨冠突骨折的手术技术;关于最佳方法的共识仍然难以捉摸。本研究旨在使用前神经血管间隔方法治疗尺骨冠突骨折,并评估其短期至中期随访的临床结果。
    方法:这项回顾性临床研究包括2018年1月至2022年12月采用前神经血管间隔入路治疗的20例尺骨冠突骨折患者。参与者包括16名男性和4名女性,年龄在20至64岁之间(平均,34.3±12.44年)。临床和放射学评估基于肘关节活动范围(ROM),视觉模拟量表(VAS)和梅奥肘部性能评分(MEPS)。使用配对t检验比较术前和最终随访的VAS和MEPS评分。
    结果:所有患者的随访时间至少为12个月(平均,12.65±1.60个月)。在最后的后续行动中,肘部ROM的测量包括2.85±3.17°的平均延伸,平均屈曲135±7.25°,平均内旋86.4±4.56°,平均旋后84.85±5.54°。所有参与者都达到了他们的目标MEPS,平均得分为97.25±4.72分,最终平均VAS评分为0.2±0.52分。末次随访时VAS评分明显低于术前,MEPS评分明显高于术前(p<0.05)。在整个随访期间,所有的骨折联合起来,受影响肘部的稳定性令人满意。
    结论:采用前神经血管间隔入路切开复位内固定治疗冠状突骨折有效地促进了尺骨冠状突骨折的解剖恢复和坚固固定。
    OBJECTIVE: Numerous surgical techniques for addressing ulnar coronoid process fractures are available; however, a consensus on the optimal approach remains elusive. This study aimed to use the anterior neurovascular interval approach for the surgical management of ulnar coronoid process fractures and to evaluate its clinical outcomes over short- to mid-term follow-up.
    METHODS: This retrospective clinical study included 20 patients with ulnar coronoid process fractures who were treated using the anterior neurovascular interval approach between January 2018 and December 2022. Participants comprised 16 males and four females, aged between 20 and 64 years (mean, 34.3 ± 12.44 years). Clinical and radiological evaluations were based on elbow joint range of motion (ROM), Visual analogue scale (VAS), and Mayo elbow performance score (MEPS). A paired t-test was used to compare the pre-operative and final follow-up VAS and MEPS scores.
    RESULTS: The follow-up duration for all patients was at least 12 months (average, 12.65 ± 1.60 months). At the final follow-up, measurements of elbow ROM included a mean extension of 2.85 ± 3.17°, mean flexion of 135 ± 7.25°, mean pronation of 86.4 ± 4.56°, and mean supination of 84.85 ± 5.54°. All participants reached their target MEPS, with an average score of 97.25 ± 4.72 points, and the final mean VAS score was 0.2 ± 0.52 points. The VAS score was significantly lower and MEPS score was higher at the final follow-up than those before surgery (p < 0.05). Throughout the follow-up period, all the fractures united, and the stability of the affected elbows was satisfactory.
    CONCLUSIONS: Employing the anterior neurovascular interval approach for open reduction and internal fixation to manage coronoid process fractures effectively facilitates anatomical restoration and robust fixation of ulnar coronoid process fractures.
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  • 文章类型: Journal Article
    用手到达头部后部的运动是日常生活的重要运动。仅在临床实践中使用的上肢功能测试的分数在计划运动改善的练习时很难用作参考。这项横断面研究旨在阐明轻度偏瘫患者瘫痪和非瘫痪上肢到达枕骨的运动学特征。纳入10例中风后偏瘫患者,这些患者曾在济经大学医院康复医学科就诊并符合资格标准。使用三维运动分析测量瘫痪和非瘫痪上肢到达头部后部的运动,和运动时间,接头角度,并计算了角速度。对这些数据进行重复测量的多变量协方差分析。在确认与二项逻辑回归模型的拟合后,使用受试者工作特征曲线计算截止值.使用随机森林聚类进行模式识别,以分析运动时间和关节角度的模式。在运动时间内,直到手到达头部后部的运动截止值为1.6s,最大肩关节屈曲角度为55°,和145°为最大肘关节屈曲角度。从头部后部到返回其原始位置的手的运动截止值为1.6s,最大肘关节屈曲角度为145°,肩关节外展最大角速度为53°/s,肘关节屈曲的最大角速度为62°/s。集群的数量是三个,四,四个是向外的非瘫痪侧,向外和返回瘫痪侧,返回非瘫痪侧,分别。这项研究获得的发现可用于轻度偏瘫患者的实践计划,这些患者旨在改善伸向枕骨的运动。
    The reaching motion to the back of the head with the hand is an important movement for daily living. The scores of upper limb function tests used in clinical practice alone are difficult to use as a reference when planning exercises for movement improvements. This cross-sectional study aimed to clarify in patients with mild hemiplegia the kinematic characteristics of paralyzed and non-paralyzed upper limbs reaching the occiput. Ten patients with post-stroke hemiplegia who attended the Department of Rehabilitation Medicine of the Jikei University Hospital and met the eligibility criteria were included. Reaching motion to the back of the head by the participants\' paralyzed and non-paralyzed upper limbs was measured using three-dimensional motion analysis, and the motor time, joint angles, and angular velocities were calculated. Repeated measures multivariate analysis of covariance was performed on these data. After confirming the fit to the binomial logistic regression model, the cutoff values were calculated using receiver operating characteristic curves. Pattern identification using random forest clustering was performed to analyze the pattern of motor time and joint angles. The cutoff values for the movement until the hand reached the back of the head were 1.6 s for the motor time, 55° for the maximum shoulder joint flexion angle, and 145° for the maximum elbow joint flexion angle. The cutoff values for the movement from the back of the head to the hand being returned to its original position were 1.6 s for the motor time, 145° for the maximum elbow joint flexion angle, 53°/s for the maximum angular velocity of shoulder joint abduction, and 62°/s for the maximum angular velocity of elbow joint flexion. The numbers of clusters were three, four, and four for the outward non-paralyzed side, outward and return paralyzed side, and return non-paralyzed side, respectively. The findings obtained by this study can be used for practice planning in patients with mild hemiplegia who aim to improve the reaching motion to the occiput.
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  • 文章类型: Journal Article
    背景:Taping刺激机械感受器,增加中枢神经系统的感觉信息,改善感觉运动同步,从而改善电机控制。然而,对肘部本体感觉的疗效尚不清楚。
    目的:本研究旨在评估健康个体使用胶带对肘部本体感觉的直接影响。
    方法:这项研究是一项双臂研究,平行组,随机化,控制,带有假应用的单盲研究。
    方法:56名健康成人以1:1的比例随机分为运动录音(n=27)或假录音(n=29)。主动关节位置感知误差(JPSE)用于在三个时间点使用通用测角仪量化本体感受:基线(BS),录音后立即(IA),录音后30分钟(30MA),在肘部弯曲70°和110°时胶带仍在原位。参与者对小组分配视而不见。弗里德曼分析评估了组内评价之间的差异,Mann-WhitneyU检验确定了组间的差异。
    结果:研究完成了56名参与者,没有辍学。在参与者中未观察到皮肤反应或不良反应,并且未排除任何测试试验。两组基线评分相似(p>0.05)。在70°(MD=-1.22;CI=(-2.33:-0.10;p<0.005;d=0.653)和110°的肘部屈曲(MD=-1.34;CI=2,47:-0.21;p<0.005;d=0.73)后,研究组中检测到显着差异。甚至在70°的30MA评价中也观察到这种统计学上显著的差异(p<0.05)。此外,在录音后,两组的JPSE均有统计学上不显著的下降趋势。
    结论:肘部本体感受可以通过运动贴膜增强,在肘部弯曲70°时,这种效果可以持续30分钟。相比之下,假录音并没有产生这样的改善。基于JPSE的差异,与假应用相比,kinesio胶带被证明更有效,并且具有更持久的影响。JPSE下降的统计学上不明显的趋势可能表明30分钟的应用时间不足以对肘部本体感觉产生统计学上的显着影响。更长的使用时间可以更好地揭示矫形器对本体感觉的影响。
    BACKGROUND: Taping stimulates the mechanoreceptors, increases sensory information to the central nervous system, and improves sensorimotor synchronization, resulting in improved motor control. However, the efficacy of taping on elbow proprioception is not clear.
    OBJECTIVE: This study aimed to evaluate the immediate effects of taping on elbow proprioception in healthy individuals.
    METHODS: This study was a two-arm, parallel-group, randomized, controlled, single-blinded study with a sham application.
    METHODS: Fifty six healthy adults were randomized 1:1 to kinesio taping (n = 27) or sham taping (n = 29). Active joint position sense error (JPSE) was used to quantify proprioception using a universal goniometer at three-time points: baseline (BS), immediately after taping (IA), and 30 minutes after taping (30MA), with the tape still in place at 70° and 110° of elbow flexion. Participants were blinded to group assignments. The Friedman analysis assessed differences between evaluations within groups, and the Mann-Whitney U test determined differences between groups.
    RESULTS: The study was completed with 56 participants and there were no dropouts. No skin reaction or adverse effect was observed in the participants and no test trial was excluded. The baseline scores of the groups were similar (p > 0.05). A significant difference was detected in the study group after kinesio taping at 70° (MD = -1.22; CI = (-2.33: -0.10; p < 0.005; d = 0.653) and 110° of elbow flexion (MD = -1.34; CI = 2,47: -0,21; p < 0.005; d = 0.73). This statistically significant difference was observed even at the 30MA evaluations at 70° (p < 0.05). Also, there was a statistically insignificant tendency to decrease in JPSE of both groups at both degrees following taping.
    CONCLUSIONS: Elbow proprioception may be enhanced by kinesio taping, and this effect could last up to 30 minutes at 70° of elbow flexion. In contrast, sham taping did not produce such an improvement. Based on the differences in JPSE, kinesio taping proved more effective and had a longer-lasting impact than the sham application. The statistically insignificant tendency to decrease in JPSE may indicate that the 30-minute application period is inadequate to create a statistically significant effect on elbow proprioception. Longer usage periods can better reveal the effects of orthoses on proprioception.
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  • 文章类型: Journal Article
    背景:鹰嘴豆囊炎可能难以治疗,导致持续性或复发性症状。囊切除术是难治性病例的常用治疗选择,但并发症发生率高。这是首次研究水热消融的安全性和有效性的体内研究,复发性或慢性鹰嘴滑囊炎的一种新的治疗方式,旨在通过用加热的盐水冲洗引起法氏囊内膜的热闭塞。
    方法:首先,为了确定安全的灌溉温度窗口,我们进行了一项动物试验。第二,在一项人体试验中,慢性病患者的法囊,在50至52°C的温度下,用3mL/s的生理盐水冲洗复发性或难治性鹰嘴滑囊炎,持续时间为180秒。患者随访6个月,允许评估手术部位以筛查不良事件,容积超声对滑囊的评估,和QuickDASH的集合,患者整体印象和临床整体印象评分,以及返回活动或工作的数据。
    结果:前瞻性地纳入了24个肘部,并经历了一个完整的水热消融周期。平均年龄为58.4岁(范围为40.5-81.5),其中男性20例,女性4例。没有一个有化脓性囊炎的临床症状。仅一例囊液培养阳性。术前法囊平均体积为11.18cc(范围4.13-30.75)。24个肘部中有18个(75%)成功治疗,在6周内表现出症状完全缓解或确定改善,并且在整个6个月的随访期间没有任何复发迹象。在对治疗有反应的患者组中,超声测量的法氏囊体积平均减少了91.9%。在没有复发的患者中,治疗前后的平均QuickDASH评分分别为13.6(范围0-50)和3.1(范围0-27.5)。显示出统计学上的显着改善。所有患者都能够在索引程序后的6周内完全恢复工作。没有发生严重不良事件。2例患者出现中度局部不良事件。提高灌溉温度不会导致更高的治疗效果。
    结论:对于复发性或慢性尺骨鹰嘴滑囊炎,在50至52度的温度下进行水热消融是一种安全的治疗选择,其并发症比开腹滑囊切除术少,且疗效相当。
    BACKGROUND: Olecranon bursitis can be difficult to treat, resulting in persistent or recurrent symptoms. Bursectomy is a frequently applied treatment option for refractory cases but has high complication rates. This is the first in vivo study to investigate the safety and efficacy of hydrothermal ablation, a new treatment modality for recurrent or chronic olecranon bursitis that aims to cause thermal obliteration of the bursal lining by irrigation with heated saline.
    METHODS: First, a pilot animal trial was set up to determine a safe irrigation temperature window. Second, in a human trial the bursae of patients with chronic, recurrent, or refractory olecranon bursitis were irrigated with a 3-mL/s flow of physiological saline for a duration of 180 seconds at temperatures between 50°C and 52°C. Patients were followed up for 6 months, allowing for assessment of the surgical site to screen for adverse events, volumetric ultrasonographic assessment of the bursae, and collection of the Quick Disabilities of the Arm, Shoulder, and Hand questionnaire (QuickDASH), Patient Global Impression Score, and Clinical Global Impression Score, as well as data on return to activities or work.
    RESULTS: Twenty-four elbows were prospectively included and underwent a full cycle of hydrothermal ablation. The mean age was 58.4 years (range 40.5-81.5), including 20 male and 4 female patients. None had clinical signs of septic bursitis. Bursal fluid cultures were positive in only 1 case. The average preoperative bursal volume was 11.18 mL (range 4.13-30.75). Eighteen of 24 elbows (75%) were successfully treated, showing a complete remission of symptoms or decided improvement within 6 weeks and without any signs of recurrence during the entire follow-up period of 6 months. The average reduction of ultrasonography-measured bursal volume was 91.9% in the group of patients who responded to treatment. In patients without recurrence, the mean QuickDASH scores before and after treatment were 13.6 (range 0-50) and 3.1 (range 0-27.5), respectively, showing a statistically significant improvement. All patients were able to fully return to work within 6 weeks after the index procedure. No serious adverse events were encountered. Moderate local adverse events were found in 2 patients. Increasing temperatures of irrigation did not result in a higher treatment efficacy.
    CONCLUSIONS: Hydrothermal ablation at temperatures between 50°C and 52°C is a safe treatment option for recurrent or chronic olecranon bursitis with fewer complications than open bursectomy and a comparable efficacy.
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