背景:Laurin-Sandrow综合征也称为四聚体镜像多指是一种罕见的先天性疾病,其特征是手的多指多指,通常与尺和/或腓骨重复有关的镜像脚和鼻子异常(鼻翼和短小柱发育不全)。作为一个病理实体,它是异质的,患者表现出各种症状。这篇综述旨在分析病情的不同方面,临床发现和治疗方法等,总结Laurin-Sandrow综合征的主要特点。
方法:评论基于PubMed上的搜索,以下术语的WebofScienceandResearchgate:“Laurin-Sandrow综合征”,“镜子手”,“镜子脚”,\“四角镜像多指\”,“腓骨双耳病”和“尺骨双耳病”。临床病例,包括评论和原始文章。
结果:由于我们的发现,我们建议对镜像手-多手光谱的Al-Qattan分类系统进行修改。
结论:尽管它的发病率极低,对该综合征的全面了解使外科医生能够选择适当的治疗方法,最终目的是提高患者的生活质量。
BACKGROUND: Laurin-Sandrow syndrome also known as tetramelic mirror-image polydactyly is a rare congenital disorder characterized classically by polysyndactyly of the hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella) often associated with ulnar and/or fibular duplication. As a pathologic entity, it is heterogeneous, the patients displaying a variety of symptoms. This
review aims to analyze the different aspects of the condition, such as clinical findings and methods of treatment to summarize the principal features of Laurin-Sandrow syndrome.
METHODS: The
review is based on searches on PubMed, Web of Science and Researchgate of the following terms: \"Laurin-Sandrow syndrome\", \"mirror hands\", \"mirror feet\", \"tetramelic mirror-image polydactyly\", \"fibular dimelia\" and \"ulnar dimelia\". Clinical cases, reviews and original articles were included.
RESULTS: As a consequence of our findings, we suggest a modification of the Al-Qattan classification system for Mirror Hand-Multiple Hand Spectrum.
CONCLUSIONS: Even though it has an extremely low incidence, a thorough understanding of the syndrome enables the surgeon to choose the appropriate treatment with the ultimate goal to improve the patient\'s life quality.