目标:制定基于共识的检查表,该检查表可用作评估全面性的最低标准,疾病成本(COI)研究的透明度和一致性。这很重要,当,例如,审查和评估COI研究,作为系统审查的一部分,或在建立经济模型时。
方法:基于共识的清单的开发过程包括六个步骤:(i)范围审查,(ii)评估和比较不同的清单及其问题,(iii)制定(初步)清单,(四)专家访谈,(五)清单的定稿,和(vi)制定解释每个问题的指导声明。
结果:结果是一份基于共识的清单,用于对COI研究的关键评估,包括三个领域的十七个主要问题(和一些其他子问题):(i)研究特征;(ii)方法和成本分析;(iii)结果和报告。制定了指导声明,描述了每个问题背后的目的和含义,并列出了最佳实践的示例。在回答检查表中的问题时,建议应用以下答案类别:是,部分,不,不适用,或不清楚。
结论:基于共识的COI研究检查表是标准化COI研究关键评估的第一步,可以被视为最低标准。核对表有助于提高全面性,COI研究的透明度和一致性,为了解决异质性,并使国际研究的方法学方法具有更好的可比性。
OBJECTIVE: To develop a
consensus-based checklist that can be used as a minimum standard to appraise the comprehensiveness, transparency and consistency of cost-of-illness (COI) studies. This is important when, for instance, reviewing and assessing COI studies as part of a systematic review or when building an economic model.
METHODS: The development process of the
consensus-based checklist involved six steps: (i) a scoping review, (ii) an assessment and comparison of the different checklists and their questions, (iii) the development of a (preliminary) checklist, (iv) expert interviews, (v) the finalization of the checklist, and (vi) the development of guidance statements explaining each question.
RESULTS: The result was a
consensus-based checklist for the critical appraisal of COI studies, comprising seventeen main questions (and some additional subquestions) across three domains: (i) study characteristics; (ii) methodology and cost analysis; and (iii) results and reporting. Guidance statements were developed describing the purpose and meaning behind each question and listing examples of best practice. The following answer categories were suggested to be applied when answering the questions in the checklist: Yes, Partially, No, Not Applicable, or Unclear.
CONCLUSIONS: The
consensus-based checklist for COI studies is a first step toward standardizing the critical appraisal of COI studies and is one that could be considered a minimum standard. The checklist can help to improve comprehensiveness, transparency and consistency in COI studies, to address heterogeneity, and to enable better comparability of methodological approaches across international studies.