背景:在诊断为炎症性肠病(IBD)的孕妇中,母体炎症环境的改变以及母体血管结构(动脉僵硬度)和功能的改变可能会影响胎儿心脏。
目的:探讨IBD妊娠胎儿心功能,揭示IBD病程与胎儿心功能的关系。
方法:前瞻性病例对照研究。
方法:病例组包括19名患有溃疡性结肠炎的孕妇和7名患有克罗恩病的孕妇,他们在研究时处于缓解状态。对照组由52名在妊娠晚期(32至33周)的胎龄相匹配的健康孕妇组成。
方法:胎儿心功能。对于患者是病例还是对照,评估是盲目的。
结果:右心室E',E\'/A\',S\',和三尖瓣环平面收缩期偏移(TAPSE)显着降低,和E/E\',心肌性能指标(MPI),IBD妊娠胎儿的等体积弛豫时间(IVRT\')明显更高。舒张功能(E/E\',E\',E\'/A\',和IVRT\'),收缩功能(S'和TAPSE),和全局函数(MPI')在案例组中被更改。母体疾病持续时间与胎儿右心室舒张功能参数之间存在显着强相关性(E/E',E,E\',E\'/A\')病例组(分别为r2=0.780;p≤0.001,r2=0.570;p≤0.001,r2=0.604;p≤0.001,r2=0.638;p≤0.001)。
结论:IBD妊娠胎儿心脏舒张和收缩功能发生改变。随着疾病持续时间的增加,尤其是胎儿心脏舒张功能可能受到影响。
BACKGROUND: The altered maternal inflammatory milieu and changes in maternal vascular structure (arterial stiffness) and function may affect the fetal heart in pregnant women diagnosed with inflammatory bowel disease (IBD).
OBJECTIVE: To investigate fetal cardiac functions in IBD pregnancies and to reveal the relationship between IBD duration and fetal cardiac functions.
METHODS: Prospective
case-control study.
METHODS: The
case group included 19 pregnant women with ulcerative colitis and seven with Crohn\'s disease who were in remission at the time of the study. The control group consisted of 52 healthy pregnant women matched for gestational age in the third trimester of pregnancy (at 32 to 33 weeks).
METHODS: Fetal cardiac functions. The assessment was blinded as to whether the patients were cases or controls.
RESULTS: The right ventricular E\', E\'/A\', S\', and tricuspid annular plane systolic excursion (TAPSE) were significantly lower, and E/E\', myocardial performance index (MPI\'), and isovolumetric relaxation time (IVRT\') were significantly higher in fetuses of IBD pregnancies. Diastolic functions (E/E\', E\', E\'/A\', and IVRT\'), systolic functions (S\' and TAPSE), and global function (MPI\') were changed in the
case group. A significantly strong correlation was between maternal disease duration and fetal right ventricle diastolic function parameters (E/E\', E, E\', E\'/A\') in the
case group (r2 = 0.780; p ≤0.001, r2 = 0.570; p ≤0.001, r2 = 0.604; p ≤0.001, r2 = 0.638; p ≤0.001, respectively).
CONCLUSIONS: Diastolic and systolic fetal cardiac functions changed in IBD pregnancies. As the disease duration increases, especially fetal cardiac diastolic functions may be affected.