UASSIGNED:哮喘是世界上最常见的慢性呼吸道疾病,估计遗传力在50%至60%之间,最近的研究表明,表观遗传机制在其发展中起着重要作用。许多前沿的表观遗传学研究技术已被应用于哮喘发病机制的研究,促进了哮喘病因学的发展,为治疗带来了新的可能。我们总结了哮喘发病机制的表观遗传学研究的最新进展。特别是从高通量分析技术的角度来看,寻找潜在的表观遗传生物标志物和可能的分子靶标,以便将来对该疾病进行干预和治疗。
UNASSIGNED:我们回顾并总结了哮喘在“转录前水平”的表观基因组研究的最新进展,包括DNA甲基化,组蛋白修饰,和染色质重塑,在“转录后水平”上,重点是非编码RNA,从高通量分析技术的角度。
UNASSIGNED:我们总结了最近不同类型的哮喘表观遗传学研究的进展,包括DNA甲基化研究[候选基因甲基化研究和全表观基因组关联研究(EWAS)],组蛋白修饰研究(组蛋白乙酰化/脱乙酰化研究和组蛋白甲基化研究),非编码RNA研究[微小RNA(miRNA),长链非编码RNA(lncRNA)和环状RNA(circRNA)],帮助读者全面了解哮喘的表观遗传学研究领域。高通量分析技术在哮喘研究中的应用,包括EWAS(DNA甲基化芯片),染色质免疫沉淀测序(CHIP-seq),microRNA测序,全转录组测序,共表达网络和竞争内源性RNA(ceRNA)分析,与主要发现一起介绍。还讨论了通过高通量分析鉴定的潜在表观遗传生物标志物和可能的分子靶标。
未经批准:表观遗传学研究已成为哮喘发病机制研究的热点。高通量表观遗传分析技术与传统生物学功能和临床研究相结合,将为哮喘的发病机制研究带来新的突破。这将改善对该疾病的遗传解释,并为精准医学的发展带来更多可能性。
UNASSIGNED: Asthma is the most common chronic respiratory disease in the world with an estimated heritability between 50% and 60%, and recent studies have shown that epigenetic mechanisms play an important role in its development. Many cutting-edge epigenetic research techniques have been applied to the study of the pathogenesis of asthma, which has promoted the development of asthma etiology and brought new possibilities for treatment. We summarized recent advances in epigenetic research of the pathogenesis of asthma, especially from the perspective of high-throughput analysis techniques, to find potential epigenetic biomarkers and possible molecular targets for the future intervention and treatment of the disease.
UNASSIGNED: We reviewed and summarized recent progress in epigenomic studies of asthma on a \"pre-transcriptional level\", including DNA methylation, histone modification, and chromatin remodeling, and on a \"post-transcriptional level\" with a focus on non-coding RNA, from the perspective of high-throughput analysis technologies.
UNASSIGNED: We have summarized the progress of different kinds of recent epigenetic studies in asthma, including DNA methylation studies [candidate genes methylation studies and epigenome-wide association study (
EWAS)], histone modification studies (histone acetylation/deacetylation studies and histone methylation studies), non-coding RNA studies [microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs)], to help the readers to gain a comprehensive insight into the epigenetic research fields for asthma. The application of high-throughput analysis techniques in asthma research, including
EWAS (DNA methylation chips), chromatin immunoprecipitation sequencing (CHIP-seq), microRNA sequencing, whole transcriptome sequencing, co-expression network and competing endogenous RNA (ceRNA) analyses, were introduced accompany with the main findings. And the potential epigenetic biomarkers and possible molecular targets identified via high-throughput analyses were also discussed.
UNASSIGNED: Epigenetic research has become a hotspot in research on the pathogenesis of asthma. The combination of high-throughput epigenetic analysis technologies and traditional biological function and clinical studies will bring new breakthrough in the pathogenesis study of asthma, which will improve the genetic interpretation of the disease and bring more possibilities for the development of precision medicine to treat it.