未经证实:先天性角化病(DC)是一种罕见的遗传性疾病,其特征是网状色素沉着三联症,指甲营养不良和口腔白斑。DC患者被认为容易受到外部压力的影响,如免疫化疗。很少有病例报告DC患者的严重治疗引起的毒性。
未经证实:一名27岁女性入院,有4个月的全血细胞减少病史,有7天的呼吸困难伴咳嗽病史。5个月前她被诊断出非霍奇金淋巴瘤.她因非霍奇金淋巴瘤接受了免疫化疗,但反复发烧,口腔溃疡,全血细胞减少症,免疫化疗期间呼吸困难和其他症状。一入场,她的呼吸道症状加重,反复感染和急性心力衰竭。
未经证实:实验室检查证实全血细胞减少症,胸部计算机断层扫描显示间质性肺病(ILD)。遗传剖析成果证实DC和TINF2一基因突变的存在。通过持续的支持和抗感染治疗,她的病情终于稳定下来。近2个月后她出院了。
UNASSIGNED:我们回顾了类似病例,发现了可能有用的共同特征。然而,报告的病例非常有限。需要更多的案例和研究。
未经证实:这些病例表明DC患者似乎更容易受到治疗毒性的影响;因此,在用化疗药物或放疗治疗这些患者时,医生应该小心。可以考虑降低强度的治疗。
UNASSIGNED: Dyskeratosis congenita (DC) is a rare inherited disease characterized by the triad of reticulate hyperpigmentation, nail dystrophy and oral leukoplakia. DC patients are considered vulnerable to external pressure, such as immunochemotherapy. There are very few cases reporting severe therapy-induced toxicities in patients with DC.
UNASSIGNED: A 27-year-old woman was admitted to our hospital with a 4-month history of pancytopenia and a 7-day history of dyspnea with coughing. She was diagnosed with non-Hodgkin\'s lymphoma 5 months ago. She received immunochemotherapy due to non-Hodgkin\'s lymphoma but experienced recurrent fever, oral ulcer, pancytopenia, dyspnea and other symptoms during immunochemotherapy. On admission, she experienced an aggravation of respiratory symptoms, recurrent infections and acute heart failure.
UNASSIGNED: Laboratory examination confirmed pancytopenia, and chest computed tomography showed interstitial lung disease (ILD). Genetic analysis results confirmed the presence of DC and a TINF2 gene mutation. With continuous supportive and anti-infection treatment, her condition finally stabilized. She was discharged from the hospital after nearly 2 months.
UNASSIGNED: We reviewed similar cases and found common features that could be useful. However, the reported cases are very limited. More cases and studies are needed.
UNASSIGNED: These cases indicate that DC patients seem more vulnerable to therapy toxicities; thus, physicians should be careful when treating these patients with chemotherapy drugs or radiation therapy. Reduced-intensity therapy may be considered.