■结直肠癌(CRC)的发病率随着时间的推移在全球范围内不断增加。这项研究调查饮酒是否与CRC风险相关。
■我们设计了一项病例对照研究,嵌套在衢州的大规模CRC筛查计划中,中国。病例为2020-2022年新诊断的CRC。使用频率匹配对对照进行随机采样。饮酒变量包括饮酒状态,频率,持续时间,和其他人。Logistic回归用于估计比值比(OR)和95%置信区间(CI)。
■在当前饮酒者中,153例和650例对照之间饮酒的粗略OR(cOR)(95%CI)为1.46(0.99,2.16),3.31(1.44,7.60)前饮酒者,1.82(1.21,2.74)在6-7天/周饮酒,饮酒1-19年为3.48(1.29,9.37)。按性别分层,女性的所有饮酒变量,但并非男性的所有饮酒变量都与CRC风险一致相关.目前饮酒男性的校正OR(aOR)(95%CI)为1.01(0.59,1.74),2.27(0.78,6.64)前饮酒男子,目前饮酒女性为4.24(1.61,11.13)。喝威士忌的aOR(95%CI)为0.19(0.04,0.83),1.89(0.86,4.17),2.25(1.05,4.83),男性饮酒≤0.5,>0.5-≤1.0,>1.0-≤1.5和>1.5升/周(P趋势=0.011)和1.82(0.85,3.92),和3.80(1.03,14.00)和9.92(2.01,49.00)女性饮酒≤0.5和>0.5升/周(P趋势=0.001),分别。
■饮酒与CRC风险增加存在性别差异,女性的相关性强于男性。男性饮用威士忌与CRC风险之间的关联呈J型。
UNASSIGNED: Colorectal cancer (CRC) incidence has been increasing worldwide over time. This
study investigated whether
drinking was associated with CRC risk.
UNASSIGNED: We designed a case-control
study nested in a mass CRC screening program in Quzhou, China. Cases were newly diagnosed CRC in 2020-2022. Controls were randomly sampled using frequency match.
Drinking variables included
drinking status, frequency, duration, and others. Logistic regressions were used to estimate odds ratio (OR) and 95 % confidence interval (CI).
UNASSIGNED: The crude OR (cOR) (95 % CI) of drinking between 153 cases and 650 controls was 1.46 (0.99, 2.16) in current drinkers, 3.31 (1.44, 7.60) in former drinkers, 1.82 (1.21, 2.74) in drinking 6-7 days/week, and 3.48 (1.29, 9.37) in
drinking 1-19 years. Stratifying by sex, all drinking variables in women but not all in men were consistently associated with CRC risk. The adjusted OR (aOR) (95 % CI) was 1.01 (0.59, 1.74) in current drinking men, 2.27 (0.78, 6.64) in former
drinking men, and 4.24 (1.61, 11.13) in current
drinking women. The aOR (95 % CI) of drinking whisky was 0.19 (0.04, 0.83), 1.89 (0.86, 4.17), 2.25 (1.05, 4.83), and 1.82 (0.85, 3.92) in men drinking ≤0.5, >0.5-≤1.0, >1.0-≤1.5, and >1.5 Liter/week (P trend = 0.011), and 3.80 (1.03, 14.00) and 9.92 (2.01, 49.00) in women drinking ≤0.5 and >0.5 Liter/week (P trend = 0.001), respectively.
UNASSIGNED: There was sex difference in drinking associated with increased risk of CRC which association was stronger in women than that in men. Men\'s association between drinking whisky and CRC risk was J-shaped.