动物和人类研究表明,三卤甲烷(THM)对骨骼具有毒性。在这项研究中,我们纳入了国家健康和营养检查调查的青少年,他们量化了血液和自来水的THM浓度[氯仿(TCM),溴二氯甲烷(BDCM),二溴氯甲烷(DBCM),和溴形(TBM)]和腰椎或全身无头(TBLH)骨矿物质密度(BMD)。血液中中药的浓度增加了2.7倍,DBCM,氯化THMs(中药的总和,BDCM,和DBCM),总THM(4个THM的总和)与下腰椎BMDz评分相关-0.06[95%置信区间(CI):-0.12,-0.01],-0.06(95%CI:-0.11,-0.003),-0.08(95%CI:-0.14,-0.02),和-0.07(95%CI:-0.13,-0.003),分别,在调整后的模型中。同样,血液BDCM增加2.7倍,DBCM,氯化THM浓度与较低的TBLHBMDz评分相关-0.10(95%CI:-0.17,-0.02),-0.10(95%CI:-0.17,-0.03),和-0.11(95%CI:-0.20,-0.01),分别。当使用自来水THM浓度来预测血液THM测量时,获得了低至中等的预测能力。值得注意的是,血液THM的负相关仅在DBCM和Br-THM的水浓度与TBLHBMDz评分之间存在.我们的发现表明,暴露于THM可能会对青少年BMD产生不利影响。
Animal and human studies have suggested that trihalomethane (THM) has toxicity to bone. In this
study, we included adolescents from the National Health and Nutrition Examination Survey who had quantified blood and tap water THM concentrations [chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and lumbar spine or total body less head (TBLH) bone mineral density (BMD). A 2.7-fold increase in concentrations of blood TCM, DBCM, chlorinated THMs (the sum of TCM, BDCM, and DBCM), and total THMs (the sum of 4 THMs) was associated with lower lumbar spine BMD z-scores by -0.06 [95% confidence interval (CI): -0.12, -0.01], -0.06 (95% CI: -0.11, -0.003), -0.08 (95% CI: -0.14, -0.02), and -0.07 (95% CI: -0.13, -0.003), respectively, in adjusted models. Similarly, a 2.7-fold increase in blood BDCM, DBCM, and chlorinated THM concentrations was associated with lower TBLH BMD z-scores by -0.10 (95% CI: -0.17, -0.02), -0.10 (95% CI: -0.17, -0.03), and -0.11 (95% CI: -0.20, -0.01), respectively. Low-to-moderate predictive power was attained when tap water THM concentrations were used to predict blood THM measurements. Notably, the inverse associations for blood THMs persisted exclusively between water concentrations of DBCM and Br-THMs and the TBLH BMD z-scores. Our findings suggest that exposure to THMs may adversely affect the adolescent BMD.