代谢性疾病是全球流行的,并对姜黄和姜黄素对代谢性疾病患者糖代谢的影响进行了系统评价和荟萃分析。
我们全面搜索了WebofScience,PubMed,Ovid(包括EMBASE和MEDLINE),Scopus,Cochrane图书馆和两个中文数据库,姜黄和姜黄素对空腹血糖(FBG)影响的随机对照研究万方和CNKI,血红蛋白A1C(HbA1c),代谢性疾病患者的空腹血清胰岛素(FSI)和HOMA-IR。FBG和HbA1c是需要分析的主要结果。有了随机效应模型,单独的荟萃分析通过逆方差进行,并报告为WMD,CI为95%。
来自17项RCT(包括22项试验)的证据表明,姜黄和姜黄素类化合物可使FBG降低-7.86mg/dL(95%CI:-12.04,-3.67mg/dL;P=0.0002),糖化血红蛋白-0.38%(95%CI:-0.52%,-0.23%;P<0.00001)和HOMA-IR=-1.01(95%CI:-1.6,-0.42;P=0.0008)。此外,在亚组分析中,干预超过8周后,他们的空腹血清胰岛素降低了-1.69mU/L(95%CI:-3.22,-0.16mU/L;P=0.03).
姜黄和姜黄素降低FBG,代谢疾病患者中HbA1c和HOMA-IR显著。此外,如果干预期超过8周,则可能对FSI浓度产生影响.然而,由于存在显著的异质性,应注意这些结果。
Metabolic diseases are globally popular, and a systematic
review and meta-analysis of turmeric and curcuminoids on glucose metabolism among people with metabolic diseases was performed.
We comprehensively searched Web of Science, PubMed, Ovid (including EMBASE and MEDLINE), Scopus, the Cochrane Library and two Chinese databases, Wanfang and CNKI for RCTs that focused on the effects of turmeric and curcuminoids on fasting blood glucose (FBG), hemoglobin A1C (HbA1c), fasting serum insulin (FSI) and HOMA-IR among patients with metabolic diseases. The FBG and HbA1c were the main outcomes to be analyzed. With random-effects models, separate meta-analyses were conducted by inverse-variance and reported as WMD with 95% CIs.
Evidence from 17 RCTs including 22 trials showed that turmeric and curcuminoids lowered FBG by - 7.86 mg/dL (95% CI: -12.04, -3.67 mg/dL; P = 0.0002), HbA1c by - 0.38% (95% CI: -0.52%, -0.23%; P < 0.00001) and HOMA-IR by - 1.01 (95% CI: -1.6, -0.42; P = 0.0008). Moreover, they decreased fasting serum insulin by - 1.69 mU/L (95% CI: -3.22, -0.16 mU/L; P = 0.03) after more than 8 weeks of intervention in a subgroup analysis.
Turmeric and curcuminiods decrease FBG, HbA1c and HOMA-IR significantly among subjects with metabolic disease. Additionally, they may have an effect on FSI concentrations if the intervention period is more than 8 weeks. However, attention should be paid to these outcomes due to the significant heterogeneity.