背景硬化性苔藓(LSEA)是生殖器和外生殖器部位的慢性炎症性皮肤病,患病率从青春期前患者的9%到绝经后患者的50%不等。聊天生成预训练变压器(ChatGPT)是一种人工智能工具,旨在基于监督和强化技术来帮助人类。在这项研究中,我们旨在使用ChatGPT评估LSEA患者的特征.方法本回顾性研究,我们纳入了2017-2022年期间在印度南部一家三级护理教学医院门诊皮肤科就诊的所有患者.有关人口统计数据的信息,LSEA的特点,合并症,和相关的自身免疫性疾病是使用医学图表审查收集的。在数据分析和手稿起草之后,评估了ChatGPT-3和ChatGPT-4在最终确定草案中的实用性。结果20例确诊为LSEA,16例(80%)和4例(20%)患者为女性和男性,分别。其中,50%的女性患者已绝经。虽然65%的患者有生殖器LSEA,30%的患者只有外型LSEA,5%的患者同时患有生殖器和生殖器外LSEA。此外,4例(20%)患者为青春期前儿童.四名男性患者中,两人(50%)年龄小于18岁,一名患者被诊断患有干燥闭塞性龟头炎。LSEA中最常见的相关特征包括关节受累(30%),高血压(25%),贫血(15%)。罕见的伴随疾病包括牛皮癣,哮喘,和鼻子上的基底细胞癌。结论LSEA可能与其他各种皮肤病相混淆,比如硬皮,白癜风,和扁平苔藓.需要高度怀疑,尤其是在儿童中,早期诊断并干预以防止进一步的并发症。它与自身免疫性疾病和合并症的关系值得进一步大规模研究。由于提供了不存在的引文,ChatGPT在文献检索中是不可靠的。ChatGPT-4优于ChatGPT-3,因为它提供的真实出版物很少。在这项研究中,ChatGPT用于总结作者在文献检索过程中确定的文章,并纠正手稿最终草稿中的语法错误。
Background Lichen sclerosus et atrophicus (LSEA) is a chronic inflammatory dermatosis of genital and extragenital sites with a prevalence ranging from 9% in prepubertal patients to 50% in postmenopausal patients. Chat generative pre-trained transformer (ChatGPT) is an artificial intelligence tool designed to assist humans based on supervised and reinforcement techniques. In this study, we aimed to evaluate the characteristics of patients with LSEA using ChatGPT. Methods In this retrospective study, we included all patients who presented to the outpatient dermatology department during 2017-2022 at a tertiary care teaching hospital in South India. Information regarding demographic data, characteristics of LSEA, comorbidities, and associated autoimmune disorders was gathered using a medical chart review. Following data analysis and drafting of the manuscript, the utility of ChatGPT-3 and ChatGPT-4 in finalizing the draft was assessed. Results Of 20 patients diagnosed with LSEA, 16 (80%) and four (20%) patients were females and males, respectively. Of them, 50% of female patients had attained menopause. While 65% of patients had genital LSEA, 30% of patients had extragenital LSEA only, and 5% of patients had both genital and extragenital LSEA. Furthermore, four (20%) patients were prepubertal children. Of four male patients, two (50%) were younger than 18 years of age, and one patient was diagnosed with balanitis xerotica obliterans. The commonest associated features in LSEA included joint involvement (30%), hypertension (25%), and anemia (15%). Rare concomitant disorders included psoriasis, asthma, and basal cell carcinoma over the nose. Conclusions LSEA may be confused with other various dermatoses, such as morphea, vitiligo, and lichen planus. A high index of suspicion is required, especially in children, to diagnose it early and intervene to prevent further complications. Its relationship with autoimmune disorders and comorbidities warrants further large-scale studies. ChatGPT was unreliable in the literature search due to the provision of non-existent citations. ChatGPT-4 was better than ChatGPT-3 since it provided few true publications. ChatGPT was used in this study to summarize the articles identified by the authors during the literature search and to correct grammatical errors in the final draft of the manuscript.