描述了新的人体组织制剂的处理和初始测试。全厚度无细胞真皮基质(ftADM)是通过对来自尸体供体的全厚度人皮肤进行脱细胞化而获得的细胞外基质(ECM)。安全,关于残余细胞含量的结果，讨论了移植物的稳定性和可用性，ECM组件的维护，和生物力学特性。对ECM的定量和定性分析表明不存在细胞碎片，而人真皮的天然结构得以维持。生物力学测试表明，刚度值与用于肌腱加固的其他商业产品相当，表明我们的ftADM不仅可以成功地用于软组织再生手术，而且在肌腱加固。描述了ftADM在肩袖增强中的第一种情况。讨论了手术期间补片的技术管理和临床结果。
The processing and initial testing of a new human tissue preparation is described. Full-thickness Acellular Dermal Matrix (ftADM) is the extracellular matrix (ECM) obtained by
decellularization of full-thickness human skin from cadaveric donors. The safety, stability and usability of the graft are discussed with respect to the results of the residual cellular content, maintenance of ECM components, and biomechanical properties. Quantitative and qualitative analysis of the ECM demonstrated the absence of cell debris, while the native structure of human dermis was maintained. Biomechanical testing showed stiffness values comparable to other commercial products used for tendon reinforcement, suggesting that our ftADM could be successfully used not only in soft tissue regeneration surgeries, but also in tendon reinforcement. First
case of ftADM in rotator cuff augmentation is described. Technical management of the patch during surgery and clinical outcomes are discussed.
