目的:原发性脑肿瘤有可能对健康造成重大危害,最终导致不可预见的死亡。尽管人们对许多疾病的理解增强了,疾病进展的精确预测仍然是一个重大挑战.这项研究的目的是调查由原发性脑肿瘤引起的意外死亡病例,并分析导致此类发生的变量。
方法:本系统综述探讨了被诊断为原发性脑肿瘤并经历意外死亡的个体的研究。它使用PRISMA标准和搜索PubMed,谷歌学者,还有Scopus.考虑的变量包括年龄,性别,症状,肿瘤类型,WHO等级,验尸结果,死亡时间-从第一次医疗报告或入院到死亡的时间,合并症,和风险因素。
结果:这项研究检查了46项研究,以分析76名患者的患者水平数据,这些患者因颅内病变而意外死亡,故意排除胶体囊肿。队列的年龄分布显示平均年龄为37岁,没有明显的性别偏好。头痛是最常见的初始症状。星形细胞瘤,脑膜瘤,胶质母细胞瘤是最常见的病变,而额叶,颞叶,和小脑是常见的位置。脑膜瘤和星形细胞瘤在入院的第一个小时内显示出更快的死亡。
结论:脑肿瘤引起的意外死亡的病因阐明了一个复杂而多样的现象。尽管意外死亡占总死亡人数的比例很小,由于漏报和误诊,很可能低估了它们的实际发生率。
OBJECTIVE: Primary brain tumors have the potential to present a substantial health hazard, ultimately resulting in unforeseen fatalities. Despite the enhanced comprehension of many diseases, the precise prediction of disease progression continues to pose a significant challenge. The objective of this study is to investigate cases of unexpected mortality resulting from primary brain tumors and analyze the variables that contribute to such occurrences.
METHODS: This systematic
review explores research on individuals diagnosed with primary brain tumors who experienced unexpected deaths. It uses PRISMA standards and searches PubMed, Google Scholar, and Scopus. Variables considered include age, gender, symptoms, tumor type, WHO grade, postmortem findings, time of death - time taken from first medical presentation or hospital admission to death, comorbidity, and risk factors.
RESULTS: This study examined 46 studies to analyze patient-level data from 76 individuals with unexpected deaths attributed to intracranial lesions, deliberately excluding colloid cysts. The cohort\'s age distribution showed an average age of 37 years, with no significant gender preference. Headache was the most common initial symptom. Astrocytomas, meningiomas, and glioblastoma were the most common lesions, while the frontal lobe, temporal lobe, and cerebellum were common locations. Meningiomas and astrocytomas showed faster deaths within the first hour of hospital admission.
CONCLUSIONS: The etiology of unforeseen fatalities resulting from cerebral tumors elucidates an intricate and varied phenomenon. Although unexpected deaths account for a very tiny proportion of total fatalities, it is probable that their actual occurrence is underestimated as a result of underreporting and misdiagnosis.