酶折叠成三维结构以分配氨基酸残基进行催化,这激发了构建模拟酶催化剂的超分子方法。超分子策略开发中的关键问题是限制和定向官能团以在人造材料中形成酶样活性位点的能力。本文介绍了具有血红素依赖性酶催化功能的超分子纳米材料的设计原理和构建。一大类金属蛋白,它依赖于血红素辅因子和空间配置的残基,通过复杂的多步机制催化不同的反应。我们专注于超分子催化剂的结构-活性关系及其在材料合成/降解中的应用。生物传感,和治疗学。还简要讨论了催化血红素蛋白反应的无血红素催化剂。在审查结束时,我们讨论了与催化剂设计和未来前景相关的挑战的展望,包括结构解析技术和设计概念的发展,目的是创造具有与天然酶相媲美的催化能力的模拟酶材料。.
Enzymes fold into three-dimensional structures to distribute amino acid residues for catalysis, which inspired the supramolecular approach to construct enzyme-mimicking catalysts. A key concern in the development of supramolecular strategies is the ability to confine and orient functional groups to form enzyme-like active sites in artificial materials. This
review introduces the design principles and construction of supramolecular nanomaterials exhibiting catalytic functions of heme-dependent enzymes, a large class of metalloproteins, which rely on a heme cofactor and spatially configured residues to catalyze diverse reactions via a complex multistep mechanism. We focus on the structure-activity relationship of the supramolecular catalysts and their applications in materials synthesis/degradation, biosensing, and therapeutics. The heme-free catalysts that catalyze reactions achieved by hemeproteins are also briefly discussed. Towards the end of the
review, we discuss the outlook on the challenges related to catalyst design and future prospective, including the development of structure-resolving techniques and design concepts, with the aim of creating enzyme-mimicking materials that possess catalytic power rivaling that of natural enzymes..