本系统综述和荟萃分析的目的是研究VDR基因多态性与乳腺癌之间的关系。通过PubMed数据库搜索文献,谷歌学者,和知识网络从2015年12月到2017年1月,包括34项研究(26,372例病例和32,883例对照)。所有统计测量均使用STATA版本11.2完成。使用I2统计量检验研究之间的异质性。Mantel-Haenszel方法和DerSimonian-Laird方法用于结合使用随机效应模型和固定效应模型的研究数据,分别。通过Egger检验评估潜在的发表偏差。还进行了敏感性分析以评估结果的质量和一致性。这项荟萃分析的结果表明,VDR基因多态性(Bsm1bbvsBB;SOR=1.18,95%CI=1.054-1.322,Apa1aavsAA;SOR=1.18,95%CI=0.87-1.59,Poly(A)LLvsSS;SOR=1.41,95%CI=1.06-1.88,FfFF=1.18,SOR=1.95%,SORCdx2、Bgl1和Taq1与乳腺癌没有相关性。因此,这项荟萃分析的发现得出结论,VDRBsm1,Apa1,Fok1和Poly(A)基因多态性可能易感乳腺癌的发展。
The purpose of this systemic
review and meta-analysis was to examine the relationship between VDR gene polymorphisms and breast cancer. Literature was searched through PubMed database, Google scholar, and the web of knowledge from December 2015 to January 2017 and consists of 34 studies (26,372 cases and 32,883 controls). All statistical measures were done using STATA version 11.2. The heterogeneity among studies was tested using I2 statistics. Mantel-Haenszel method and DerSimonian-Laird method were used to combine data from studies using both random-effect model and fixed-effect model, respectively. Potential publication bias was evaluated by Egger\'s test. Sensitivity analysis was also performed to evaluate the quality and consistency in results. The results of this meta-analysis revealed that VDR gene polymorphisms (Bsm1 bb vs BB; SOR = 1.18, 95% CI = 1.054-1.322, Apa1 aa vs AA; SOR = 1.18, 95% CI = 0.87-1.59, Poly (A) LL vs SS; SOR = 1.41, 95% CI = 1.06-1.88, Fok1 ff + Ff vs FF; SOR = 1.25, 95% CI = 0.896-1.759, Apa1 aa+Aa vs AA; SOR = 1.13, 95% CI = 0.95-1.35, Poly (A) LL + LS vs SS; SOR = 1.19, 95% CI = 1.00-1.43, Poly (A) L vs S; SOR = 1.18, 95% CI = 1.03-1.35) are associated with the breast cancer. Cdx2, Bgl1, and Taq1 do not show association with breast cancer. Thus, the finding of this meta-analysis concluded that VDR Bsm1, Apa1, Fok1, and Poly (A) gene polymorphisms may be susceptible for breast cancer development.