在这次审查中,我们已经报道了几种查尔酮衍生物的抗氧化机制和结构-抗氧化活性关系,在最近的调查中,基于密度泛函理论(DFT)计算,考虑自由基清除和金属螯合能力。抗氧化机制包括氢原子转移(HAT)、顺序质子损失电子转移(SPLET),单电子转移,然后是质子转移(SET-PT),顺序质子损失氢原子转移(SPLHAT),连续双质子损失电子转移(SdPLET),连续三重质子损失双电子转移(StPLdET),顺序三重质子损失三重电子转移(StPLtET),双顶帽,双SPLET,双SET-PT,三顶帽子,三重SET-PT,三重SPLET,质子耦合电子转移(PCET),单电子转移(SET),自由基加合物形成(RAF)和自由基加合物形成,然后是氢原子夺取(RAF-HAA)。此外,使用不同的溶剂化模型也考虑了溶剂效应。考虑到抗氧化剂分子中存在的羟基和甲氧基的数量和位置等各种因素,已经讨论了清除不同活性氧和氮物种(ROS/RNS)的可行性。清除反应性物种后形成的物种的稳定性,取代基的性质,空间效应,等。这篇综述为设计具有更好抗氧化潜力的新化合物开辟了新的视角。
In this
review, we have reported the antioxidant mechanisms and structure-antioxidant activity relationship of several chalcone derivatives, investigated in the recent past, based on the density functional theory (DFT) calculations, considering free radical scavenging and metal chelation ability. The antioxidant mechanisms include hydrogen atom transfer (HAT), sequential proton loss electron transfer (SPLET), single electron transfer followed by proton transfer (SET-PT), sequential proton loss hydrogen atom transfer (SPLHAT), sequential double proton loss electron transfer (SdPLET), sequential triple proton loss double electron transfer (StPLdET), sequential triple proton loss triple electron transfer (StPLtET), double HAT, double SPLET, double SET-PT, triple HAT, triple SET-PT, triple SPLET, proton-coupled electron transfer (PCET), single electron transfer (SET), radical adduct formation (RAF) and radical adduct formation followed by hydrogen atom abstraction (RAF-HAA). Furthermore, solvent effects have also been considered using different solvation models. The feasibility of scavenging different reactive oxygen and nitrogen species (ROS/RNS) has been discussed considering various factors such as the number and position of hydroxyl as well as methoxy groups present in the antioxidant molecule, stability of the species formed after scavenging reactive species, nature of substituent, steric effects, etc. This
review opens new perspectives for designing new compounds with better antioxidant potential.