BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease with chronic pain that gradually becomes incapacitating and negatively influences the health-related quality of life (HRQoL). This study estimates HRQoL in RA using the EuroQol five dimensions (EQ-5D) tool and its association with functional status and disease activity.
METHODS: RA patients (n = 320) aged above 18 years, visiting outpatient clinic at a tertiary care multispecialty hospital in south India were the study participants. Sociodemographic, clinical, and laboratory data were collected from them. EQ-5D-5L questionnaire and the EQ Global Health Visual Analogue Scale (EQ-VAS) were used to measure HRQoL. Disease activity was measured using Disease Activity Score-28 (DAS-28), and the Health Assessment Questionnaire (HAQ) was used to assess functional status. Pearson\'s correlation and multiple linear regression were used to measure association, and statistical significance was considered at p < 0.05.
RESULTS: The EQ-5D utility score was 0.54 ± 0.36, pain and anxiety were the most affected domains, and the mean EQ-VAS was 63.05 ± 18.54%. A moderate to high disease activity was present in 85% (DAS-28 > 3.2), and a severe functional disability in 32.8% (HAQ > 1.5) of study participants. The mean EQ-5D scores for RA patients were 0.78 (0.65-0.90) for no disease activity, 0.73 (0.65-0.80) for mild, 0.53 (0.32-0.74) for moderate and 0.47 (0.32-0.62) for high disease activity. In multiple linear regression analysis, HAQ and age independently predicted EQ-5D.
CONCLUSIONS: RA significantly impacts HRQoL, and interventions focussing on pain and anxiety management are essential. The study\'s EQ-5D values could help estimate Quality Adjusted Life Years (QALY) while conducting economic evaluation studies in RA within an Indian context.

Seismic methods are extensively used in coal mining for expanding resource discoveries and definition as well as for mine monitoring. However, the use of borehole seismic methods is relatively uncommon due to the high cost of borehole seismic acquisition using conventional downhole tools. The introduction of distributed acoustic sensing (DAS), which uses optical fibres to record seismic data, has dramatically increased the cost-effectiveness of borehole seismic methods. Fibre-optic cables are inexpensive and, once deployed in a borehole, can be abandoned or used later for further monitoring of the subsurface. The case study presented here concerns the use of DAS to record a 3D VSP (vertical seismic profiling) for coal seam exploration in Queensland, Australia. This study trialled effective strategies for deploying cables into boreholes and demonstrated how this technology could be incorporated into the standard coal exploration process. The final processing results produced a high-resolution 3D seismic cube where the coal seams below the basalt cover are clearly identifiable around the boreholes. Permanent installation of the fibre-optic cables into a set of boreholes provides immediate benefits of 3D seismic imaging and can create additional value in utilising these sensors for further discrete or continuous subsurface measurements, including stability monitoring of underground workings and detection of methane accumulations.

A cross-sectional, representative sample from adolescent girls of higher senior secondary schools was collected for the study. We analyzed the data from 600 Punjabi Indian female adolescents (200 from humanities, 200 from commerce, and 200 from science stream) aged 15-17 years who were randomly selected from government and private schools. The symptoms of depression, anxiety, and stress were assessed by the DAS questionnaire. Overall prevalence was 50.8%, 58.7%, and 68% for depression, anxiety, and stress, respectively. A significant difference was reported for depression (.000), anxiety (.000), and stress (.002) between adolescents of three streams. The results of the study point out that there is a necessity for some interventions to educate adolescent girls about the negative effects of stress, depression, and anxiety on their body.

Parents play a significant role in the development of dental anxiety in their adolescent children. This cross-sectional study aimed to evaluate the influence of family milieu on adolescents\' dental anxiety. The level of dental anxiety (Dental Anxiety Scale-DAS) was evaluated in 100 adolescent dental patients (ages 13-18 years) and their parents. Parents supplied information about family demographics and their personal experiences of dental treatment. Concomitantly, the family\'s behavior was observed during the dental encounter. The adolescents\' mean DAS score was 9.83 ± 2.05. Adolescents\' DAS was higher when their parents\' memories from their own dental encounters were negative. A positive correlation was found between adolescents\' dental anxiety and that of their father (r = 0.52, p < 0.001) and mother (r = 0.79, p < 0.001). The following variables showed a significant ability to predict adolescents\' dental anxiety (stepwise regression): mother\'s DAS (B = 0.57), adolescent\'s behavior at the dental visit (B = 0.87), being the firstborn child (B = -0.44), father\'s DAS (B = 0.13), and mother\'s level of education (B = -0.10). The results showed that intra-family relationships and behavior, parents\' education, dental fear, and memories from previous treatments play an important role in defining the level of dental anxiety in their adolescent children.

UNASSIGNED: We aimed to evaluate quality of life (QoL), disease activity, compliance to treatment, patient and physician preferences for route of administration (RoA), status of health and pain in RA patients starting advanced treatments or needing a switch, and the factors associated with patient preferences.
UNASSIGNED: A multicentre, prospective, observational and 1-year follow-up study was conducted, between 2015 and 2020, in adult RA patients using advanced treatments for the first time or needing a switch in their current treatments. All the data collected were entered into electronic case report forms. DAS in 28 joints with ESR [DAS28-4(ESR)], EuroQol 5-Dimensional Questionnaire (EQ-5D), HAQ Disability Index (HAQ-DI), Compliance Questionnaire for Rheumatology (CQR-19), Work Productivity and Activity Impairment Instrument (WPAI) and Patient Global Assessment-Visual Analogue Scale (PGA-VAS) questionnaires were used for longitudinal assessments.
UNASSIGNED: Four hundred and fifty-nine patients were enrolled. Three hundred and eight patients (67.1%) attended the final study visit at 12 months and were included for comparative analyses. Irrespective of RoA, the disease activity and QoL improved significantly at 12 months, whereas compliance worsened. At baseline and 12 months, EQ-5D and DAS28-4(ESR) scores were significantly correlated (P < 0.001). The WPAI scores changed significantly in favour of better outcomes over 12 months after initiation of advanced treatment or switching (P < 0.001). A higher proportion of patients preferred an oral RoA, in comparison to physicians (53.6% vs 31.4%; P < 0.001). Patient and physician RoA preferences were independent of gender, age, disease duration, advanced treatment type and the EQ-5D-3L, DAS28-4(ESR), HAQ-DI, PGA-VAS and CQR-19 scores at baseline.
UNASSIGNED: The oral route was more frequently preferred by patients compared with physicians, although patients\' preference rates showed a slight increase towards the end of the treatment, which might be an important factor for RA outcomes. Better control of disease activity and QoL were achieved at 12 months, regardless of RoA.

OBJECTIVE: Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. The aim of this study was to investigate the emotional network of frontal lobe DAS using the multivariate Granger causality analysis (GCA) method, a technique that can estimate the association among the brain areas to analyze functional magnetic resonance imaging (fMRI) data collected from DAS and no depression after stroke (NDAS).
METHODS: Thirty-six first-time ischemic right frontal lobe stroke patients underwent resting-state fMRI (rs-fMRI) scans. The clinical assessment scale used for screening subjects was as follows: the 24-item Hamilton Rating Scale for Depression (HAMD-24), the National Institutes of Health Stroke Scale (NIHSS), the Mini-Mental State Examination (MMSE), and the Barthel Index (BI). The multivariate GCA method was used to analyze fMRI data collected from DAS and NDAS.
RESULTS: The results showed positive regulations in the order from the ventromedial prefrontal cortex (VMPFC), the anterior cingulate cortex (ACC), and the amygdala (AMYG) to the thalamus, and when the interaction order is opposite, the moderating effect is negative. The thalamus could predict the negative activity of the insular (IC) via the ACC. The dorsolateral prefrontal cortex (DLPFC) could predict the activity of the ACC via the temporal pole (TP).
CONCLUSIONS: This study found a VMPFC-ACC-AMYG-thalamus emotional circuit to explain the network between different brain regions associated with DAS. The DLPFC and TP play an important role in the emotional regulation of DAS, and the function of the IC is regulated negatively by the thalamus. These findings advance the neural theory of DAS, which is based on the functional relationship between different brain areas.

BACKGROUND: Functional gene polymorphisms modulating neuroplasticity might mediate brain longitudinal structural changes in schizophrenia. The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis.
METHODS: Patients were part of a large epidemiological and longitudinal intervention program of first-episode psychosis, carried out at the University Hospital Marqués de Valdecilla, Cantabria, Spain. Eighty first-episode patients and 54 healthy controls were included in the final analyses. Brain magnetic resonance imaging (baseline and 3-year follow-up) and BDNF genotype, and clinical and functional outcome were investigated.
RESULTS: We did not detect significant association between brain changes and BDNF Val66Met polymorphism variations in patients and controls (all p>0.060). At baseline, there were no significant associations between brain anomalies and BDNF genotype. Functional deficits were similar in Met-carrier and Val homozygote patients after 3-year follow-up (X(2) = 0.66; p = 0.564); there was no relationship between significant volume change across time and functional outcome. Otherwise, Met-carrier controls had significant high rates of alcohol-consumption (p = 0.019) compared to Val homozygote controls.
CONCLUSIONS: Our findings do not support the notion that BDNF genotype variations may mediate brain macroscopic morphological changes across time.