背景:根据一些研究,饮食可与CRY1基因多态性相互作用,可能与肥胖和心血管疾病(CVD)的风险有关。所以,这项研究调查了超重女性和肥胖女性中CRY1多态性和AHEI对心血管危险因素的交互作用.
方法:这项横断面研究是对377名年龄在18-48岁(BMI≥25kg/m2)的超重和肥胖的伊朗妇女进行的。通过使用食物频率问卷(FFQ)评估147个项目的饮食摄入量。AHEI是根据以前的研究计算的。评估人体测量和生化测量,并使用生物电阻抗分析方法进行身体分析。通过限制性片段长度多态性(PCR-RFLP)方法对rs2287161进行基因分型。根据rs2287161基因型将对象分为三组。
结果:我们的发现确定C等位基因的患病率为51.9%,G等位基因的患病率为48.0%。平均年龄和BMI分别为36.6±9.1岁和31±4kg/m2。在控制了混杂因素(BMI,年龄,总能量摄入,和身体活动),这项研究表明,CC基因型和坚持AHEI对高LDL的几率有显著的交互作用(OR=1.94,95%CI=1.24-3.05,交互作用的P=0.004),高血压(OR=1.80,95%CI=1.11~2.93,交互作用P=0.01)和高血糖(OR=1.56,95%CI=0.98~2.47,交互作用P=0.05)。
结论:这项研究表明坚持AHEI可以降低高LDL的几率,高血压,rs2287161的CC基因型和高血糖。
BACKGROUND: According to some studies, diet can be interaction with CRY1 polymorphism and may be related to obesity and the risk of cardiovascular diseases (CVD). So, this
study examined the interaction between CRY1 polymorphism and AHEI on cardiovascular risk factors in overweight women and women with obesity.
METHODS: This cross-sectional
study was performed on 377 Iranian women with overweight and obesity aged 18-48(BMI ≥ 25 kg/m2). Dietary intake was evaluated by the use of a food frequency questionnaire (FFQ) with 147 items. The AHEI was calculated based on previous studies. Anthropometric and biochemical measurements were assessed and the bioelectrical impedance analysis method was used for body analysis. The rs2287161 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method. Objects were divided into three groups based on rs2287161 genotypes.
RESULTS: Our findings determined that the prevalence of the C allele was 51.9% and the G allele was 48.0%. The mean age and BMI were 36.6 ± 9.1years and 31 ± 4 kg/m2 respectively. After controlling for confounders (BMI, age, total energy intake, and physical activity), this
study demonstrated that there was a significant interaction between CC genotype and adherence to AHEI on odds of hyper LDL (OR = 1.94, 95% CI = 1.24-3.05, P for interaction = 0.004), hypertension (OR = 1.80, 95% CI = 1.11-2.93, P for interaction = 0.01) and hyperglycemia (OR = 1.56, 95% CI = 0.98-2.47, P for interaction = 0.05).
CONCLUSIONS: This
study indicated that adherence to AHEI can reduce the odds of hyper LDL, hypertension, and hyperglycemia in the CC genotype of rs2287161.