背景:IgG4相关疾病是一种病因不明的纤维炎症性疾病,会影响多个器官系统,包括心血管系统.虽然大多数报道的心血管受累病例主要与主动脉有关,有零星的孤立心脏受累报告。
方法:本文介绍了一例IgG4相关的全身性疾病,症状提示为限制性心肌病。随后的心脏磁共振成像显示弥漫性心肌心包受累,以心包增厚和增强为特征,伴有心外膜下和心肌浸润。考虑到我们案例中心脏受累的罕见,我们对IgG4相关疾病中各种模式的心脏受累的现有文献进行了全面回顾,以及可用于准确识别和评估的诊断方式。
结论:本病例报告阐明了识别和评估IgG4相关全身性疾病的心脏表现以促进及时诊断和适当治疗的重要性。
BACKGROUND: IgG4-related disease is a fibro-inflammatory disorder with an unknown etiology, which can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are primarily associated with the aorta, there have been sporadic reports of isolated cardiac involvement.
METHODS: This paper presents a documented case of IgG4-related systemic disease with symptoms indicative of restrictive cardiomyopathy. Subsequent Cardiac Magnetic Resonance imaging revealed diffuse myopericardial involvement, characterized by pericardial thickening and enhancement, accompanied by subepicardial and myocardial infiltration. Considering the rarity of cardiac involvement in our case, we conducted a thorough
review of the existing literature pertaining to various patterns of cardiac involvement in IgG4-related disease, as well as the diagnostic modalities that can be employed for accurate identification and assessment.
CONCLUSIONS: This case report sheds light on the importance of recognizing and evaluating cardiac manifestations in IgG4-related systemic disease to facilitate timely diagnosis and appropriate management.