有必要对现有变应性鼻炎(AR)文献的质量和有效性进行严格检查,以增进对AR患者的理解并适当地将这些知识转化为临床护理。为了评估现有的AR文献,对AR感兴趣的国际多学科专家发表了《过敏和鼻学国际共识声明:过敏性鼻炎》(ICAR:AR)。
使用前面描述的方法,制定了与AR相关的具体主题。每个主题都被分配了一个文献综述,循证审查(EBR),或ICAR:AR文件中可用的证据和目的所规定的基于证据的建议审查(EBRR)格式。在对每个主题进行迭代审查之后,ICAR:AR文件由所有作者进行综合和审查,以达成共识.
ICAR:AR文档涉及超过100个与AR相关的主题,包括诊断,病理生理学,流行病学,疾病负担,AR发展的危险因素,过敏测试模式,治疗,以及与AR相关的其他条件/合并症。
这项对AR文献的批判性审查已经确定了几个优点;提供者可以确信治疗决策得到了严格研究的支持。然而,AR文献也存在很大差距。这些知识差距应被视为改进的机会,通常,我们教的东西和我们实践的药物都不是基于最好的质量证据。本文件旨在强调AR文献的优缺点,以确定未来AR研究的领域和增进理解。
Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International
Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).
Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for
consensus.
The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.
This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.