新生儿和儿童的听力损失是一个公共卫生问题,由于高患病率和对其发展的负面影响。早期发现和干预儿童听力损失可能会减轻这些负面影响。全球已经建立了基于人群的新生儿听力筛查计划,以识别有先天性听力损失风险的儿童,并跟踪有迟发性或进行性听力损失风险的儿童。本文提出了系统评价方案,旨在审查与儿童永久性听力损失相关的风险因素,包括先天性的,早期,或迟发性。与进行性听力损失相关的风险因素将作为次要目标进行研究。
将调查来自以下数据库的科学文献:MEDLINE,OvidMEDLINE(R)每日和OvidMEDLINE(R),Embase,和CINAHL。主要结果是永久性双侧或单侧听力损失,先天性发作或儿童期发作(出生至18岁)。次要结果是进行性听力损失。研究必须报告与永久性听力损失相关的危险因素的数据;危险因素可能在出生时或以后出现,并导致立即或延迟的听力损失。随机对照试验,准实验研究,非随机比较和非比较研究,和案例系列将包括在内。将使用定量研究的定性评估工具(麦克马斯特大学)评估偏倚的风险。如果可以对某一小节的研究进行数据汇总,我们将使用荟萃分析技术汇集数据。如果无法聚合数据,将进行定性综合。我们将使用建议等级评估来评估整体证据的质量和强度,开发和评估(等级)。系统审查遵循系统审查和荟萃分析(PRISMA)建议的首选报告项目。
由此产生的信息将为安大略省婴儿听力计划的省级听力学监测协议的更新提供信息,并将适用于全球范围内的早期听力检测和干预(EHDI)计划。
我们已经在国际前瞻性系统审查登记册(PROSPERO)中注册了该协议,注册号CRD42018104121。
Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects. Population-based newborn hearing screening programs have been established worldwide to identify children at risk for congenital hearing loss and to follow children at risk for late onset or progressive hearing loss. This article presents the protocol for a systematic
review that aims to
review the risk factors associated with permanent hearing loss in children, including congenital, early, or late onset. Risk factors associated with progressive hearing loss will be investigated as a secondary aim.
Scientific literature from the following databases will be investigated: MEDLINE, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), Embase, and CINAHL. The primary outcome is a permanent bilateral or unilateral hearing loss with congenital onset or onset during childhood (birth to 18 years). The secondary outcome is progressive hearing loss. Studies must report data on risk factors associated with permanent hearing loss; risk factors may be present at birth or later and result in immediate or delayed hearing loss. Randomized controlled trials, quasi-experimental studies, nonrandomized comparative and non-comparative studies, and case series will be included. The risk of bias will be assessed using the Qualitative Assessment Tool for Quantitative Studies (McMaster University). If aggregation of data is possible for a subsection of studies, we will pool data using meta-analysis techniques. If aggregation of data is not possible, a qualitative synthesis will be presented. We will assess the quality and strength of the overall body of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The systematic
review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations.
The resulting information will inform the update of a provincial audiological surveillance protocol for the Ontario Infant Hearing Program and will be applicable to early hearing detection and intervention (EHDI) programs worldwide.
We have registered the protocol in the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018104121.