背景:在介入手术前决定是否继续服用或停止服用阿司匹林是疼痛医生的主要关注点。许多关于在侵入性手术前停用阿司匹林的指南已经发表;然而,建议不一致,不考虑个体血小板功能.此外,许多研究表明,服用这种药物的患者阿司匹林抵抗的患病率很高。
目的:确定在介入疼痛治疗前停用阿司匹林的必要性与个体血小板功能的关系。
方法:多中心,横断面研究。
方法:大学附属医院。
方法:我们通过使用商用血小板功能分析仪中的胶原/肾上腺素盒测量患者的闭合时间,检查了计划进行介入性疼痛手术的患者的血小板功能。将患者分为服用阿司匹林或不服用阿司匹林组(A组或N组,分别)。计算并比较各组间血小板功能正常/异常的患者比例。
结果:本研究共纳入1,111例患者。A组,56.4%(102/181)血小板功能正常,而43.6%(79/181)显示血小板功能异常。在N组中,85.8%(798/930)和14.2%(132/930)显示血小板功能正常和异常,分别。
结论:实验室的比例,未评估临床阿司匹林抵抗.影响血小板功能的因素没有详尽的研究。
结论:服用阿司匹林的患者血小板功能正常的高患病率表明,此类患者在手术前没有必要停药。即使不服用阿司匹林的患者也可能发生血小板功能异常。因此,在介入手术之前,应根据具体情况测量和考虑血小板功能,应根据这些因素决定停用阿司匹林.
BACKGROUND: Deciding whether to continue or discontinue aspirin prior to interventional procedures is a major concern for pain physicians. Many
guidelines have been published on the discontinuation of aspirin before invasive procedures; however, the recommendations are inconsistent and do not consider individual platelet function. Furthermore, many studies have shown a high prevalence of aspirin resistance in patients taking this medication.
OBJECTIVE: To determine the necessity of discontinuing aspirin prior to interventional pain procedures in relation to individual platelet function.
METHODS: Multicenter, cross-sectional study.
METHODS: University-affiliated hospitals.
METHODS: We examined platelet function among patients scheduled for an interventional pain procedure by measuring their closure time using
collagen/epinephrine cartridges in a commercial platelet-function analyzer. The patients were categorized into either an aspirin-taking or nonaspirin-taking group (Group A or Group N, respectively). The proportion of patients who showed normal/abnormal platelet function was calculated and compared between the groups.
RESULTS: A total of 1,111 patients were included in this study. In Group A, 56.4% (102/181) showed normal platelet function, whereas 43.6% (79/181) showed abnormal platelet function. In Group N, 85.8% (798/930) and 14.2% (132/930) showed normal and abnormal platelet function, respectively.
CONCLUSIONS: The proportion of laboratory, not clinical aspirin resistance was evaluated. Factors affecting platelet function were not investigated exhaustively.
CONCLUSIONS: The high prevalence of normal platelet function in patients taking aspirin suggests no necessity of discontinuation before procedures in such patients. Abnormal platelet function can occur even in patients who are not taking aspirin. Therefore, platelet function should be measured and considered on a case-by-case basis prior to interventional procedures, and discontinuation of aspirin should be decided based on these factors.