背景:创伤诱导的凝血病(TIC)是一种常见的,可能危及生命的凝血病,以异常凝血和出血为特征。尽管已经提出了几种治疗方法用于TIC,其有效性和安全性尚不清楚.Further,已经进行了许多关于创伤的系统评价和荟萃分析;然而,根据我们的知识,没有专门针对TIC管理的系统评价和荟萃分析。因此,需要对TIC干预措施的现有证据进行全面综合.
目的:本系统综述和荟萃分析旨在评估TIC治疗干预措施的有效性和安全性。
方法:我们将对TIC患者严重创伤的随机和非随机对照试验以及观察性研究进行系统评价和荟萃分析。干预措施将包括施用凝血因子浓缩物,氨甲环酸,和血液成分产品。对照组将通过顺序输血或给予安慰剂来管理。主要结果将是住院死亡率。我们将搜索MEDLINE(PubMed)的电子数据库,WebofScience,和Cochrane中央受控试验登记册。两名审稿人将独立筛选标题和摘要,检索所选文章的全文,提取必要的数据。我们将应用统一的标准来评估与基于Cochrane偏倚风险工具的个体随机对照试验和非随机试验相关的偏倚风险。风险比率值将表示为点估计,CI为95%。连续变量将表示为平均差及其95%CIs和P值。我们将使用等级(建议评估的等级,发展,和评估)方法。本综述将是第一个系统评价和荟萃分析,提供有关TIC管理干预措施的有效性和安全性的信息。包括凝血因子浓缩物的给药,氨甲环酸,和血液成分产品。本研究方案不需要伦理批准和患者同意,当我们对公开数据进行系统回顾和荟萃分析时,没有任何人类参与者的直接参与。
结果:我们将使用PRISMA(系统评价和荟萃分析的首选报告项目)流程图对符合条件的研究的选择进行总结。结果将在总结证据的表格中呈现。荟萃分析的结果将使用数字和森林地块来描述。
结论:本系统综述将提供有关使用凝血因子浓缩物的疗效和安全性的最新信息,氨甲环酸,和TIC患者的血液成分产品。据我们所知,没有专门针对TIC治疗的系统评价和荟萃分析.
背景:UMIN注册表UMIN000050170;https://tinyurl.com/yr8pcrj6。
■DERR1-10.2196/49582。
BACKGROUND: Trauma-induced coagulopathy (TIC) is a common and potentially life-threatening coagulopathy as a result of traumatic injury, characterized by abnormal blood clotting and bleeding. Although several treatments have been proposed for TIC, their effectiveness and safety remain unclear. Further, numerous systematic reviews and meta-analyses on trauma have been conducted; however, to our knowledge, there is no systematic review and meta-analysis that specifically focuses on TIC management. Therefore, a comprehensive synthesis of the available evidence on interventions for TIC is needed.
OBJECTIVE: This systematic
review and meta-analysis aim to evaluate the effectiveness and safety of interventions for the management of TIC.
METHODS: We will conduct a systematic review and meta-analysis of randomized and nonrandomized controlled trials as well as observational studies regarding severe trauma in patients with TIC. The interventions will include administration of
coagulation factor concentrates, tranexamic acid, and blood component products. The control group will be managed with an ordinal transfusion or administered placebo. The primary outcome will be in-hospital mortality. We will search the electronic databases of MEDLINE (PubMed), Web of Science, and the Cochrane Central Register of Controlled Trials. Two reviewers will independently screen the titles and abstracts, retrieve the full text of the selected articles, and extract essential data. We will apply uniform criteria for evaluating the risk of bias associated with individual randomized controlled trials and nonrandomized trials based on the Cochrane risk-of-bias tool. Risk ratio values will be expressed as point estimates with 95% CIs. Continuous variables will be expressed as the mean difference along with their 95% CIs and P values. We will assess the strength of evidence using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. This
review will be the first systematic
review and meta-analysis providing information on the effectiveness and safety of interventions for the management of TIC, including the administration of
coagulation factor concentrates, tranexamic acid, and blood component products. Ethics approval and patient consent were not required for this study protocol, as we conducted a systematic review and meta-analysis of publicly available data, without any direct involvement of human participants.
RESULTS: We will summarize the selection of the eligible studies using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. The results will be presented in a table summarizing the evidence. The results of the meta-analysis will be depicted using figures and forest plots.
CONCLUSIONS: This systematic review will provide updated information on the efficacy and safety of using
coagulation factor concentrates, tranexamic acid, and blood component products for patients with TIC. To our knowledge, there is no systematic review and meta-analysis that specifically focuses on treatments for TIC.
BACKGROUND: UMIN registry UMIN000050170; https://tinyurl.com/yr8pcrj6.
UNASSIGNED: DERR1-10.2196/49582.