■卵巢癌肉瘤是一种罕见的卵巢癌病理类型,具有高度侵袭性,最常见于子宫部位的女性生殖道。在这里,我们探索临床病理特征,诊断,鉴别诊断,和卵巢癌肉瘤的治疗选择。
■我们分析了一例癌肉瘤的临床资料,观察其组织学形态和免疫组织化学特征,检测到同源重组修复缺陷基因突变,并回顾了相关文献。
■一名76岁更年期妇女因腹胀到我院就诊,排尿困难,还有便秘.超声检查显示子宫和盆腔异常,建议病人接受手术.右卵巢癌肉瘤的免疫组织化学结果如下:CK分数(+),波形蛋白分数(+),CK5/6焦点(+),p16(+),p53大约70%(+),WT-1焦点(+),ER焦点(+),PR部分(+),Her-2(1+),CK7分数(+),CK20病灶(+),CD99分数(+),CD10分数(+),CD56焦点(+),c-kitfoci(+),SMA零件(+),desmin焦点(+),PD-L1(-),SALL4(-),OCT3/4(-),p63(-),p40(-),D2-40(-),抑制素(-),PLAP(-),CD30(-),和Ki67热点在大约80%(+)。患者接受肿瘤细胞减灭术和辅助化疗。目前,她正在接受16个月的随访,总体情况良好。
■癌肉瘤的诊断依赖于组织病理学检查和癌肉瘤与未成熟畸胎瘤的鉴别。目前癌肉瘤的治疗方案仍以肿瘤细胞减灭术和含铂化疗为主,靶向治疗的研究仍在进行中。
UNASSIGNED: Carcinosarcoma of the ovary is a rare pathological type of ovarian cancer that is highly aggressive and occurs most frequently in the female reproductive tract at the site of the uterus. Herein, we explore the clinicopathological features, diagnosis, differential diagnosis, and treatment options for carcinosarcoma of the ovary.
UNASSIGNED: We analyzed the clinical data of a
case of carcinosarcoma, observed its histological morphology and immunohistochemical characteristics, detected the homologous recombination repair deficiency gene mutation, and reviewed the relevant literature.
UNASSIGNED: A 76-year-old menopausal woman visited our hospital because of abdominal distension, difficulty in urination, and constipation. Ultrasonography demonstrated abnormalities in the uterus and pelvic cavity, suggesting that the patient should undergo surgery. Immunohistochemical findings of carcinosarcoma of the right ovary were as follows: CK fraction (+), vimentin fraction (+), CK5/6 foci (+), p16 (+), p53 in approximately 70% (+), WT-1 foci (+), ER foci (+), PR part (+), Her-2 (1+), CK7 fraction (+), CK20 foci (+), CD99 fraction (+), CD10 fraction (+), CD56 foci (+), c-kit foci (+), SMA part (+), desmin foci (+), PD-L1 (-), SALL4 (-), OCT3/4 (-), p63 (-), p40 (-), D2-40 (-), inhibin (-), PLAP (-), CD30 (-), and Ki67 hotspot in approximately 80% (+). The patient underwent tumor cytoreduction and adjuvant chemotherapy. Currently, she is being followed up for 16 months and has a good general condition.
UNASSIGNED: The diagnosis of carcinosarcoma relies on histopathological examination and differentiation of carcinosarcoma from immature teratoma. The current therapeutic regimen for carcinosarcoma is still based on tumor cytoreduction and platinum-containing chemotherapy; research on targeted therapy is still in progress.