轻度创伤性脑损伤或运动相关脑震荡的诊断对所有临床医生来说都是一个挑战,玩家,参与接触运动的教练和家长。目前,没有有效的客观生物标志物可用于评估运动中脑震荡的存在或严重程度,因此,有必要依靠主观措施,如症状的自我报告,这取决于运动员的合作。如果漏诊,与重复损伤相关的健康风险很大,因此,客观的生物标志物在辅助诊断和预后决策方面具有很大的价值。
在尿液和唾液中建立一组非侵入性MicroRNA生物标志物,用于快速诊断运动相关脑震荡,并研究这些生物标志物在辅助诊断中的动力学和临床效用。预后和回归决策。
观测,prospective,在2017-2018年和2018-2019年橄榄球联盟赛季之间招募多中心队列研究。在英格兰高级职业国内橄榄球比赛的两个最高等级中,职业橄榄球运动员将被前瞻性地招募到这项研究中。在这个季节,将确定三组:进入世界橄榄球头部伤害评估(HIA)协议的运动员,未受伤的控制运动员和肌肉骨骼损伤的控制运动员。将在多个时间点从这些运动员身上收集唾液和尿液,与HIA协议和返回播放过程中的关键时间相吻合。
已获得伦理批准。汇编和分析的结果将在有关颅脑外伤患者护理的国家和国际会议上发表。结果也将提交给同行评审和在主题期刊/文献中发表。
The diagnosis of mild traumatic brain injury or sports-related concussion is a challenge for all clinicians, players, coaches and parents involved in contact sports. Currently, there is no validated objective biomarker available to assess the presence or severity of concussion in sport, and so it is necessary to rely on subjective measures like self-reporting of symptoms which depend on the cooperation of the athlete. There is a significant health risk associated with repetitive injury if the diagnosis is missed, and so there is great value in an objective biomarker to assist diagnostic and prognostic decisions.
To establish a panel of non-invasive MicroRNA biomarkers in urine and saliva for the rapid diagnosis of sports-related concussion and investigate the kinetics and clinical utility of these biomarkers in assisting diagnostic, prognostic and return-to-play decisions.
Observational, prospective, multicentre cohort
study recruiting between the 2017-2018 and 2018-2019 Rugby Union seasons. Professional rugby players in the two highest tiers of senior professional domestic rugby competition in England will be recruited prospectively to the
study. During the season, three groups will be identified: athletes entering the World Rugby Head Injury Assessment (HIA) protocol, uninjured control athletes and control athletes with musculoskeletal injuries. Saliva and urine will be collected from these athletes at multiple timepoints, coinciding with key times in the HIA protocol and return-to-play process.
Ethics approval has been obtained. The compiled and analysed results will be presented at national and international conferences concerning the care of patients with traumatic brain injury. Results will also be submitted for peer review and publication in the subject journals/literature.