背景:常染色体显性遗传非综合征性智力障碍22是一种由ZBTB18基因引起的罕见遗传疾病。这种疾病会影响身体的各个部位,导致智力残疾。值得注意的是,迄今为止仅报告了31例这种疾病。由于症状严重程度可能不同,医生在准确诊断方面可能面临挑战。熟悉这种疾病的症状,以获得正确的诊断和基本的医疗护理是至关重要的。
方法:有一例6岁男孩甲状腺异常不明的病例报告,全球发育迟缓,脑MRI中白质的异常信号。然而,他没有生长迟缓,小头畸形,call体发育不全,癫痫,或畸形面部特征。临床全外显子组测序揭示了ZBTB18基因中的从头致病性变异(c.187delC,p.Arg403Alafs*60),这是一个以前未报告的网站。这种变体导致肽链合成的过早终止,导致不完整的多肽链。
方法:常染色体显性遗传的非综合征性智力和残疾22综合征和甲状腺功能障碍。
方法:康复训练。
结果:个人在运动技能方面遇到困难,跑步时显得笨拙。他努力表达自己并形成完整的句子,主要依靠手势和指向。
结论:精神发育迟滞的临床表现,常染色体显性,22型(MRD22)复杂多样。尽管可以根据典型的临床症状做出早期诊断,我们的研究表明,全外显子组测序对于MRD22的诊断是必要的.
BACKGROUND: Autosomal dominant non-syndromic intellectual disability 22 is a rare genetic disorder caused by the ZBTB18 gene. This disorder affects various parts of the body, leading to intellectual disability. It is noteworthy that only 31 cases of this disorder have been reported thus far. As the symptom severity may differ, doctors may face challenges in diagnosing it accurately. It is crucial to be familiar with this disorder\'s symptoms to receive proper diagnosis and essential medical care.
METHODS: There is a
case report of a 6-year-old boy who had an unexplained thyroid abnormality, global developmental delay, and an abnormal signal of white matter in brain MRI. However, he did not have growth retardation, microcephaly, corpus callosum hypoplasia, epilepsy, or dysmorphic facial features. Clinical whole exome sequencing revealed a de novo pathogenic variant in the ZBTB18 gene (c.1207delC, p. Arg403Alafs*60), which is a previously unreported site. This variant causes the premature termination of peptide chain synthesis, leading to incomplete polypeptide chains.
METHODS: Autosomal dominant non-syndromic intellectual and disability 22 syndrome and thyroid dysfunction.
METHODS: Rehabilitation training.
RESULTS: The individual is experiencing difficulty with their motor skills, appearing clumsier while running. He struggles with expressing themselves and forming complete sentences, relying mostly on gestures and pointing.
CONCLUSIONS: The clinical presentations of mental retardation, autosomal dominant, type 22 (MRD22) are complicated and varied. Although early diagnosis can be made according to typical clinical symptoms, whole exome sequencing is necessary for diagnosing MRD22, as our study indicates.