背景:本系统综述旨在对人口统计学方面进行全面调查,临床病理特征,上皮发育不良的程度,和光化性唇炎的恶性转化率。
方法:本研究遵循系统评价和荟萃分析指南的首选报告项目,并在国际系统评价前瞻性注册中心(CRD42020201254)注册。使用PubMed/MEDLINE执行了没有年份和语言限制的搜索,Embase,虚拟健康图书馆,Scopus,WebofScience,灰色文学包括提供光化性唇炎患者信息的研究,不包括那些有其他疾病或其他类型唇炎的一般信息的人。使用乔安娜·布里格斯研究所的工具探索了偏见的风险。使用荟萃分析和亚组分析进行叙事和定量数据综合。还进行了关联测试。
结果:共纳入13项研究(728例患者)。最普遍的临床症状是干燥(99%),嘴唇朱红和皮肤之间的界限模糊(82%),缩放比例(69%),和萎缩(69%)。关于上皮发育不良,轻度发育不良的患病率(34.2%),其次是中等(27.5%),和严重(14.9%)。恶变率为14%。结壳,溃疡,红斑区域与唇癌相关(p<0.001),结垢与光化性唇炎相关(p<0.001)。
结论:这项研究揭示了光化性唇炎的几个特征,提供该疾病的概述。建议新的研究有助于制定临床标准标准化的政策指南,能够对光化性唇炎进行更严格和均匀的分析。
BACKGROUND: This systematic
review aimed to conduct a complete investigation of the demographic aspects, clinicopathological features, degrees of epithelial dysplasia, and malignant transformation rate of actinic
cheilitis.
METHODS: The study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered in the International Prospective Register of Systematic Reviews (CRD42020201254). A search without year and language restrictions was performed using PubMed/MEDLINE, Embase, Virtual Health Library, Scopus, Web of Science, and gray literature. Studies that provided information on patients with actinic
cheilitis were included, excluding those with general information on other diseases or other types of
cheilitis. Risk of bias was explored using the Joanna Briggs Institute tool. Narrative and quantitative data syntheses were performed using meta-analyses and subgroup analyses. Association tests were also performed.
RESULTS: Thirteen studies (728 patients) were included. The most prevalent clinical signs were dryness (99%), blurred demarcation between the lip vermilion and skin (82%), scaling (69%), and atrophy (69%). Regarding epithelial dysplasia, a prevalence of mild dysplasia (34.2%), followed by moderate (27.5%), and severe (14.9%). The malignant transformation rate was 14%. Crusts, ulcerations, and erythematous areas were associated with lip carcinoma (p < 0.001), and scaling was associated with actinic cheilitis (p < 0.001).
CONCLUSIONS: This study revealed several features of actinic
cheilitis, providing an overview of the disease. It is suggested that new studies help develop policy guides for the standardization of clinical criteria, enabling more rigorous and homogeneous analysis of actinic cheilitis.