细胞外基质(ECM)是结构蛋白的网络,糖蛋白和蛋白聚糖,帮助独立细胞聚集和形成高度组织化的功能结构。ECM用于多种目的,并且是组织结构和功能的必要组分。最初,ECM的作用仅限于被动功能,例如为组织提供机械强度和同一性,作为细胞的屏障执行平台。了解ECM在组织功能中的适当作用的大门随着细胞受体的发现而打开,ECM结合并影响细胞活动的整合素。理解和利用ECM控制细胞功能的潜力已成为近几十年来非常感兴趣的话题。提供不同的观点来研究参与发展计划的过程,伤口愈合和肿瘤进展。在另一条战线上,防止细胞周期错误的调节机制一直是大量研究的主题。正如许多疾病所预期的那样,最臭名昭著的癌症,与它们的功能缺陷有关。这篇综述的重点是ECM,通过不同的方法,影响体细胞细胞周期的进展,并详细介绍了粘附复合物之间功能通讯的分子机制,信号通路和细胞周期机制。
The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and proteoglycans that assists independent cells in aggregating and forming highly organized functional structures. ECM serves numerous purposes and is an essential component of tissue structure and functions. Initially, the role of ECM was considered to be confined to passive functions like providing mechanical strength and structural identity to tissues, serving as barriers and platforms for cells. The doors to understanding ECM\'s proper role in tissue functioning opened with the discovery of cellular receptors, integrins to which ECM components binds and influences cellular activities. Understanding and utilizing ECM\'s potential to control cellular function has become a topic of much interest in recent decades, providing different outlooks to study processes involved in developmental programs, wound healing and tumour progression. On another front, the regulatory mechanisms operating to prevent errors in the cell cycle have been topics of a titanic amount of studies. This is expected as many diseases, most infamously cancer, are associated with defects in their functioning. This
review focuses on how ECM, through different methods, influences the progression of the somatic cell cycle and provides deeper insights into molecular mechanisms of functional communication between adhesion complex, signalling pathways and cell cycle machinery.