背景:小窝蛋白-1(CAV1)是小窝的基本结构成分,通过复杂的细胞信号通路调节细胞过程,并影响致瘤性。然而,CAV1(rs7804372)多态性在消化性癌症中的作用仍不确定.通过Meta分析评价CAV1基因多态性对消化道肿瘤易感性的影响,为精准治疗提供依据。
方法:PubMed的数据库,EMBASE,GoogleScholar和CNKI用于检索截至2020年6月已发表的有关CAV1(rs7804372)多态性和消化系统癌症易感性的研究。两名研究人员进行了研究筛选,数据提取,根据纳入和排除标准分别进行方法学质量评价。采用ReviewManager5.3软件进行Meta分析。
结果:纳入了6项病例对照研究,包括2477名消化系统癌症患者和2477名健康对照。汇总结果显示,CAV1rs7804372(T29107A)多态性增加了等位基因发生消化道肿瘤的风险(Tvs.A:优势比(OR)1.33,95%置信区间(CI):1.15-1.53,P<0.01),纯合(TTvs.AA:OR1.72,95%CI:1.31-2.26,P<0.01),杂合子(TAvs.AA:OR1.47,95%CI:1.21-1.78,P<0.01),占优势(TTvs.TA+AA:OR1.32,95%CI:1.18-1.48,P<0.01),和隐性比较模型(TT+TA与AA:OR1.61,95%CI:1.26-2.07,P<0.01)。
结论:我们的结果表明,CAV1(rs7804372)多态性可能会改变消化系统癌症的发生,CAV1(rs7804372)的T等位基因或TT基因型的存在可能会增加消化系统癌症的风险。
BACKGROUND: Caveolin-1 (CAV1) is an essential structural component of caveolae, regulates cellular processes through complex cellular signaling pathways, and influences tumorigenicity. However, the role of the CAV1 (rs7804372) polymorphism in digestive cancers remains inconclusive. The meta-analysis was performed to evaluate the effect of CAV1 polymorphism on digestive cancer susceptibility and to provide a basis for precise treatment.
METHODS: The databases of PubMed, EMBASE, Google Scholar and CNKI were used to retrieve the published studies on CAV1 (rs7804372) polymorphism and susceptibility to digestive cancers up to June 2020. Two researchers conducted study screening, data extraction, and methodological quality evaluation separately according to inclusion and exclusion criteria.
Review Manager 5.3 software was used to conduct the meta-analysis.
RESULTS: Six case-control studies were enrolled, including 2477 patients with digestive cancers and 2477 healthy controls. The pooled results showed that the CAV1 rs7804372 (T29107A) polymorphism increased the risk of digestive cancer occurrence in the allele (T vs. A: odds ratio (OR) 1.33, 95% confidence interval (CI): 1.15-1.53, P < .01), homozygous (TT vs. AA: OR 1.72, 95% CI: 1.31-2.26, P < .01), heterozygous (TA vs. AA: OR 1.47, 95% CI: 1.21-1.78, P < .01), dominant (TT vs. TA + AA: OR 1.32, 95% CI: 1.18-1.48, P < .01), and recessive comparing models (TT + TA vs. AA: OR 1.61, 95% CI: 1.26-2.07, P < .01).
CONCLUSIONS: Our results indicate that the CAV1 (rs7804372) polymorphism may modify the occurrence of digestive cancers, and the presence of T allele or TT genotype of the CAV1 (rs7804372) may increase the risk of digestive cancers.