Caustic

苛性碱
  • 文章类型: Case Reports
    背景:在儿童中几乎是偶然发生的,在成人中大多是故意的。摄入腐蚀性物质会对胃肠道造成不同程度的损害。根据损伤的严重程度,手术可能是治疗计划的一部分。
    方法:一名32岁的男子在吞下排水管清洁器后转诊至我院。由于腹膜炎的证据和内窥镜检查结果,他接受了紧急手术。在手术过程中,坏死部位,包括食道,胃,十二指肠,胰头,空肠的初始部分,被切除了。然后,六个月后,进行结肠间置术以重建胃肠道。
    结论:像创伤患者一样,治疗有腐蚀性损伤的患者从对气道的初步调查开始,呼吸,和流通状态。在最初的48小时内,早期食管镜检查用于评估损伤量。透壁性坏死或穿孔的证据是手术的最重要指征,和外科手术是每个病人特有的。食管胃切除术是严重胃肠道损伤的最常见的手术,但是在较少的情况下,可能需要切除更多的腹部器官。
    结论:本病例报告强调迫切需要进一步研究和制定处理胃肠道广泛坏死的苛性损伤的循证指南。我们对这种罕见病例的经验强调了此类指南在改善患者预后方面的重要性。
    BACKGROUND: Caustic ingestion almost occurs accidentally in children and mostly intentionally in adults. The ingestion of caustic substances can cause various degrees of damage to the gastrointestinal tract. Depending on the severity of the injury, surgery may be a part of the treatment plan.
    METHODS: A 32-year-old man was referred to our hospital after swallowing drain cleaner. Due to evidence of peritonitis and endoscopy results, he underwent emergency surgery. During the surgery, necrotic parts, including the esophagus, stomach, duodenum, head of the pancreas, and initial part of the jejunum, were resected. Then, after six months, colon interposition surgery was done to reconstruct the gastrointestinal tract.
    CONCLUSIONS: Like trauma patients, managing patients with caustic injuries begins with an initial survey of the airway, breathing, and circulation status. In the first 48 h, early esophagoscopy is indicated to evaluate the amount of injury. Evidence of transmural necrosis or perforation is the most important indication for surgery, and surgical procedures are specific to each patient. Esophagogastrectomy is the most common surgery in cases of severe gastrointestinal injuries, but removing more abdominal organs may be needed in fewer cases.
    CONCLUSIONS: This case report underscores the urgent need for further research and the development of evidence-based guidelines in managing caustic injury with extensive necrosis in the gastrointestinal tract. Our experience with this rare case highlights the importance of such guidelines in improving patient outcomes.
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  • 文章类型: Journal Article
    尽管是毒理学领域中遇到的最衰弱的条件之一,对急性腐蚀性中毒的毒素缺乏中和措施,这促进了中毒后深部组织的进行性接触损伤。在中毒的急性期和患者的长期随访期间,仍然存在许多争议。这里,我们报告了一例严重的硝酸故意中毒并发上消化道大面积损伤的病例,多重狭窄形成,和完全吞咽困难.连续的内窥镜扩张和空肠造口术饲管的插入是必要的,和潜在的精神疾病对患者的预后产生负面影响。我们得出的结论是,需要采用跨学科的方法来适当减少腐蚀引起的病变和后遗症的程度。损伤的早期内镜标测对于更好地预测中毒的演变和可能的并发症至关重要。介入和重建外科手术可以显着提高腐蚀性物质中毒后患者的预期寿命和生活质量。
    Despite being one of the most debilitating conditions encountered in the field of toxicology, there is a lack of neutralization measures for the toxins involved in acute corrosive poisoning, and this promotes progressive contact injury of deep tissues after poisoning has occurred. Multiple controversies still surround management strategies during the acute phase of poisoning and the long-term follow-up of the patient. Here, we report a severe case of intentional poisoning with nitric acid complicated by extensive injury of the upper digestive tract, multiple stricture formation, and complete dysphagia. Serial endoscopic dilation and insertion of a jejunostomy feeding tube were necessary, and underlying psychiatric illness negatively affected the outcome of the patient. We conclude that an interdisciplinary approach is necessary to properly reduce the extent of lesions and sequelae induced by corrosion. Early endoscopic mapping of injuries is of major importance to better predict the evolution and possible complications of poisoning. Interventional and reconstructive surgical procedures may significantly improve the life expectancy and quality of life of patients following intoxication with corrosive substances.
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  • 文章类型: Journal Article
    未经证实:腐蚀性咽食管狭窄是危及生命的损伤,具有重要的管理困难,缺乏明确的治疗指南。这项研究的目的是评估我们机构严重的腐蚀性咽食管狭窄的手术程序和结果。
    UNASSIGNED:回顾性分析了2006年6月至2018年12月在国家心胸中心因严重苛性咽食管损伤而接受手术的29例患者。年龄分布,性别,管理程序,手术后的并发症,并对结果进行了分析。
    未经评估:有17名男性。平均年龄为11.7岁(范围为2-56岁)。所有病人都不小心吞下了苛性钠,除了摄入不明物质的年龄最大的病人.治疗程序包括15例(51.7%)患者的咽成形术,结肠瓣增强咽食管成形术(CFAP)在10(34.5%),和气管造口术的咽喉成形术4例(13.8%)。有1例胸骨后粘连带移植物阻塞,1例术后返流伴夜间返流。无颈部吻合口漏发生。大多数患者需要口服喂养的康复训练不到一个月。随访期为1至12年。在此期间有四名患者死亡;两名是术后立即死亡,两名发生晚。一名患者失去了随访。
    未经批准:腐蚀性咽食管狭窄的手术效果令人满意。结肠瓣扩张咽食管成形术减少了手术前气管造口术的需要,我们的病人开始吃得早,没有吸入。
    UNASSIGNED: caustic pharyngoesophageal strictures are life-threatening injuries with important management difficulties, lacking clear therapeutic guidelines. The aim of this study is to evaluate the surgical procedures and outcomes of severe caustic pharyngoesophageal strictures in our institution.
    UNASSIGNED: a total of 29 patients who underwent surgery for severe caustic pharyngoesophageal injury at the National Cardiothoracic Center from June 2006 to December 2018 were retrospectively reviewed. The age distribution, sex, management procedures, complications after surgery, and the outcome were analyzed.
    UNASSIGNED: there were 17 males. The mean age was 11.7 years (range 2- 56 years). All patients accidentally swallowed caustic soda, except the oldest patient who ingested an unidentified substance. The treatment procedures included colopharyngoplasty in 15 (51.7%) patients, colon-flap augmentation pharyngoesophagoplasty (CFAP) in 10 (34.5%), and colopharyngoplasty with tracheostomy in 4 (13.8%). There was one case of graft obstruction from a retrosternal adhesive band and one case of postoperative reflux with nocturnal regurgitation. No cervical anastomotic leak occurred. Rehabilitative training for oral feeding was required for less than a month in most patients. Follow-up period ranged from one to twelve years. Four patients died within this period; two were immediate post-operative deaths and two occurred late. One patient was lost to follow-up.
    UNASSIGNED: outcome of surgery for caustic pharyngoesophageal stricture is satisfactory. Colon-flap augmentation pharyngoesophagoplasty reduces the need for tracheostomy before surgery, and our patients start eating early without aspiration.
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