目的:决明子是具有阿育吠陀民族医学记录的蚕科植物。它在传统医学中用于治疗支气管炎,哮喘,咳嗽,结膜炎,白皮病,肾脏和肝脏疾病,便秘,肿瘤,性病溃疡,头痛,痔疮和伤口愈合。初步的体外和体内研究为其使用提供了有价值的科学证据。这篇综述旨在总结报道的生药学,传统用途,C.absus的植物化学和药理潜力,同时确定植物进一步研究的潜在领域。
结果:该综述包括有关证据基础治疗潜力的文献,从1935年到2016年,使用发表在同行评审期刊上的文章,ethno植物学教科书,以及通过电子搜索获得全球认可的科学数据库(Elsevier,谷歌学者,PubMed,Scopus,Springer,WebofScience,Wiley在线图书馆)。Kew植物园数据库和植物清单用于验证科学名称。在许多体外和体内模型中的不同药理学实验已经证明了C.absus抗高血压的潜力,抗生育,抗真菌药,抗炎,抗高血糖,抗糖基化,抗菌活性,α-淀粉酶抑制活性,抗氧化和还原活性等。chaksine,iso-chaksine,饱和和不饱和脂肪酸,大黄酚,芦荟大黄素和多种化合物也被报道。毒性研究揭示了C.absus在2000mg/kg的剂量下的无毒性质,然而,植物具有生殖毒性,可用作节育或流产。
结论:报告的活性表明,有足够的药理潜力开发C.absus作为高血压药物,感染,糖尿病及其并发症。然而,研究方案的异质性和相互矛盾的结果掩盖了重复这些研究的能力.所以,未来的研究应该按照最佳实践进行复制。更多的毒理学研究将有助于临床试验研究的进展。C.absus的各种民族医学用途尚未得到评估。
OBJECTIVE: Cassia absus is a plant of the family fabaceae with Ayurvedic ethnomedical records. It is used in traditional medicine for the treatment of bronchitis, asthma, cough, conjunctivitis, leucoderma, renal and hepatic diseases, constipation, tumors, venereal ulcer, headache, hemorrhoids and wound healing. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its use. This
review aims to summarize reported pharmacognosy, traditional uses, phytochemistry and pharmacological potential of C. absus while identifying potential areas of further research of plant.
RESULTS: The
review comprises literature pertaining to the evidence base therapeutic potential, pharmacognosy and phytochemistry of C. absus spanning from 1935 to 2016 using published articles in peer-reviewed journals, ethno botanical text books, and worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library). Kew Botanical Garden databases and the Plant List were used to authenticate the scientific names. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of C. absus with antihypertensive, antifertility, antifungal, anti-inflammatory, anti-hyperglycemic, anti-glycation, antibacterial activity, α- amylase inhibitory activity, antioxidant and reducing activitity etc. chaksine, iso-chaksine, saturated and unsaturated fatty acids, chrysophanol, aloe-emodin and a wide range of chemical compounds have also been reported. Toxicity studies reveal the nontoxic nature of C. absus at a dose of 2000 mg/kg, however, plant possess reproductive toxicity and can be used as birth control or abortifacient.
CONCLUSIONS: Reported activities suggest that there is sufficient pharmacological potential for developing C. absus as a drug for hypertension, infections, diabetes and its complications. However, heterogeneity in study protocol and conflicting results mask the ability to replicate these studies. So, future studies should be replicated in line with best practices. More toxicological studies would aid the progress to clinical trial studies. Various ethno medical uses of C. absus have not been evaluated yet.