结节病样肉芽肿性炎症(SLGI)定义为不符合系统性结节病标准的患者发生非坏死性上皮样肉芽肿。已知它的发生与不同的条件有关,包括恶性肿瘤,感染,使用某些药物和无机物。据我们所知,迄今为止,现有文献缺乏关于副神经节瘤中SLGI的任何描述.本研究描述了颈动脉体副神经节瘤(CBP)中SLGI的第一例。一名54岁的女性患者出现前颈部肿胀27年,没有任何其他症状。超声检查显示胸骨后延伸的多结节性甲状腺肿和颈部右侧40x30x22mm的实性病变,这暗示了CBP。病人接受了甲状腺全切除术,通过另一个纵向切口切除右侧宫颈肿块。甲状腺标本的组织病理学检查显示了多结节性甲状腺肿的发现。右侧宫颈肿块的切片证实诊断为CBP伴多发,形状良好,中小型,与多核巨细胞相关的非坏死性上皮样肉芽肿,指示SLGI。非坏死性上皮样细胞肉芽肿(如SLGI),与结节病中观察到的相同,可能很少在不符合系统性结节病标准的患者中观察到;然而,已观察到它们与各种肿瘤有关。因此,将它们与实际的结节病区分开来至关重要,因为误诊可能会导致严重的后果。伴随副神经节瘤的SLGI的存在是极其罕见的现象。由于这个原因,很难断定它是否能提供更好的预后。
Sarcoid-like granulomatous inflammation (SLGI) is defined as the development of non-necrotizing epithelioid granulomas in patients who do not meet the criteria for systemic sarcoidosis. Its occurrence is known to be linked to diverse conditions, including malignancies, infections, the use of certain drugs and inorganic substances. To the best of our knowledge, the available literature to date lacks any description regarding SLGI in a paraganglioma. The present study describes the first
case of SLGI in a carotid body paraganglioma (CBP). A 54-year-old female patient presented with anterior neck swelling for 27 years without any other symptoms. An ultrasonography revealed a multinodular goiter with retrosternal extension and a solid lesion on the right side of the neck measuring 40x30x22 mm, which was suggestive of a CBP. The patient underwent a total thyroidectomy, and the right-side cervical mass was resected via another longitudinal incision. A histopathological examination of the thyroid specimen revealed findings of a multinodular goiter. Sections from the right-side cervical mass confirmed the diagnosis of CBP accompanied by multiple, well-formed, small-medium sized, non-necrotizing epithelioid granulomas associated with multinucleated giant cells, indicative of SLGI. Non-necrotizing epithelioid cell granulomas (as with SLGIs), identical to those observed in sarcoidosis, may rarely be observed in patients who do not meet the criteria of systemic sarcoidosis; however, they have been observed in association with various neoplasms. It is thus crucial to distinguish them from actual sarcoidosis, as misdiagnoses may lead to severe consequences. The presence of SLGIs accompanying a paraganglioma is an extremely rare phenomenon. Due to this, it is difficult to conclude if it confers a better prognosis or not.