■挥发性有机化合物(VOCs)是空气污染和烟草烟雾的主要成分,两个已知的心血管疾病危险因素。挥发性有机化合物在环境中普遍存在,来源广泛,包括生物质的燃烧,化石燃料,和消费产品。在普通人群中,特定VOCs与缺血性心脏病(IHD)死亡率之间存在关联的直接证据很少。
■在一项病例队列研究中(按年龄组分层,性别,residence,和吸烟),嵌套在基于人群的Golestan队列研究中(n=50,045,40-75岁,58%的女性,入学人数:2004-2008)在伊朗东北部,我们使用超高效液相色谱-电喷雾串联质谱测定了20种与吸烟相关的VOC生物标志物的尿中浓度.我们计算了风险比(HR)和95%置信区间(CI)与IHD死亡率在2018年随访期间,使用Cox回归模型调整年龄,种族,教育,婚姻状况,身体质量指数,身体活动,财富,和尿可替宁。
有575例非病例来自随机亚组,601名参与者死于IHD,平均(标准差)年龄,58.2(9.3)年,中位随访8.4年。重要协会[第3次与第一三元组,HR(95%CI),P为趋势]在丙烯酰胺的生物标志物之间观察到[1.68(1.05,2.69),0.025],丙烯腈[2.06(1.14,3.72),0.058],丙烯醛[1.98(1.30,3.01),0.003和2.44(1.43,4.18),0.002],苯乙烯/乙苯[1.83(1.19,2.84),0.007和1.44(1.01,2.07),0.046],二甲基甲酰胺/甲基异氰酸酯[2.15(1.33,3.50),0.001],和1,3丁二烯[2.35(1.52,3.63),<0.001]和IHD死亡率。这些关联与吸烟无关,他们只存在于非吸烟亚组。
■我们的研究结果提供了直接证据,证明暴露于多种挥发性有机化合物与广泛的家庭和商业用途以及这些暴露多年后的IHD死亡率之间存在关联。这些结果强调了普通人群中VOC暴露作为心血管疾病的危险因素的重要性,并强调了生物监测非烟草VOC暴露的重要性。
UNASSIGNED: Volatile organic compounds (VOCs) are major components of air pollution and tobacco smoke, two known risk factors for cardiovascular diseases. VOCs are ubiquitous in the environment and originate from a wide range of sources, including the burning of biomass, fossil fuels, and consumer products. Direct evidence for associations between specific VOCs and ischemic heart disease (IHD) mortality in the general population is scarce.
UNASSIGNED: In a
case-cohort study (stratified by age groups, sex, residence, and tobacco smoking), nested within the population-based Golestan cohort study (n = 50,045, 40-75 years, 58% women, enrollment: 2004-2008) in northeastern Iran, we measured urinary concentrations of 20 smoking-related VOC biomarkers using ultra high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. We calculated hazard ratio (HR) and 95% confidence interval (CI) for their associations with IHD mortality during follow-up to 2018, using Cox regression models adjusted for age, ethnicity, education, marital status, body mass index, physical activity, wealth, and urinary cotinine.
UNASSIGNED: There were 575 non-cases from random subcohort and 601 participants who died from IHD, mean (standard deviation) age, 58.2 (9.3) years, with a median of 8.4 years follow-up. Significant associations [3rd vs. 1st tertile, HR (95% CI), P for trend] were observed between biomarkers of acrylamide [1.68(1.05,2.69), 0.025], acrylonitrile [2.06(1.14,3.72), 0.058], acrolein [1.98(1.30,3.01), 0.003 and 2.44(1.43,4.18), 0.002], styrene/ethylbenzene [1.83(1.19,2.84), 0.007 and 1.44(1.01,2.07), 0.046], dimethylformamide/methylisocyanate [2.15(1.33,3.50), 0.001], and 1,3butadiene [2.35(1.52,3.63),<0.001] and IHD mortality. These associations were independent of tobacco smoking, and they were only present in the non-smoking subgroup.
UNASSIGNED: Our findings provide direct evidence for associations between exposure to several VOCs with widespread household and commercial use and IHD mortality many years after these exposures. These results highlight the importance of VOC exposure in the general population as a risk factor for cardiovascular diseases and underline the importance of bio-monitoring non-tobacco VOC exposure.