传统上,副肿瘤性视网膜病变已分为两组:黑色素瘤相关视网膜病变(MAR)和癌症相关视网膜病变.MAR发生在转移性皮肤或葡萄膜黑色素瘤的个体中,其特征是夜视,照片,和可变的视力丧失。在大多数情况下,眼底外观基本正常。最近,已有多例MAR样视网膜病变与视网膜色素上皮和神经感觉视网膜脱离相关的报道.这种临床表现被称为副肿瘤性卵黄样视网膜病。我们描述了一名患有转移性皮肤黑色素瘤的80岁男子,他发展了副肿瘤卵黄样视网膜病变。第一次,摘除术标本的组织病理学提供了与内部核和外部丛状层局灶性异常相关的临床病理疾病。
Traditionally, the paraneoplastic retinopathies have been classified into two groups: melanoma-associated retinopathy (MAR) and cancer-associated retinopathy. MAR occurs in individuals with metastatic cutaneous or uveal melanoma and is characterized by nyctalopia, photopsias, and variable vision loss. In most cases, the fundus is essentially normal in appearance. More recently, there have been multiple reports of a MAR-like retinopathy with associated detachments of the retinal pigment epithelium and neurosensory retina. Such a clinical presentation has been termed paraneoplastic vitelliform retinopathy. We describe an 80-year-old man with metastatic cutaneous melanoma who developed paraneoplastic vitelliform retinopathy. For the first time, histopathology from enucleation specimens provides a clinicopathologic disease correlation with focal abnormalities in the inner nuclear and outer plexiform layers.