简介:癌症相关成纤维细胞(CAFs)是肿瘤微环境的重要组成部分,参与癌症进展的各个方面,并被认为是肿瘤免疫逃避的贡献者。近年来,CAFs在各种肿瘤类型中的作用引起了越来越多的关注。在这项工作中,我们进行了全面的文献计量学分析,以揭示研究轨迹并突出CAF领域的新兴领域.方法:在WebofScience核心收藏中进行了系统搜索,以识别2000年至2023年之间发表的关于CAF的文章/评论。利用先进的文献计量工具,如VOSviewer,CiteSpace,和在线网站,我们检查并可视化了出版物趋势,地理贡献,机构隶属关系,期刊突出,作者合作,和值得注意的参考文献,关键词,和基因。结果:我们的分析包括5190篇出版物,表明与CAF相关的年度出版物和引文呈快速增长趋势。中国和美国在出版物方面成为最重要的贡献者,资助机构,和国际合作。乳腺癌是研究最多的肿瘤,其次是结肠直肠癌,胰腺癌,前列腺癌,还有胃癌.基于共现和突发关键字,我们确定了以下研究课题,包括免疫细胞(T细胞,B细胞,肿瘤相关巨噬细胞),肿瘤免疫微环境(抗肿瘤免疫,免疫浸润,免疫抑制),免疫疗法(PD-L1),microRNAs(miRNA),细胞外囊泡(外泌体),多发性肿瘤(胰腺导管腺癌,膀胱癌,头颈部鳞状细胞癌),抗肿瘤药(吉西他滨,顺铂耐药),生物信息学(泛癌症),上皮-间质转化(干性),FAPIPET/CT,DNA甲基化,等。,将来可能会受到持续的关注。此外,TGFB1,IL-6,TNF,TP53和VEGFA成为在CAFs领域获得最大研究关注的前5个基因。KEGG富集分析强调,研究最多的前20个基因主要与HIF-1和Toll样受体信号通路相关。讨论:总之,我们的文献计量分析全面概述了CAF领域的研究状况。它包含当前状态,不断演变的模式,和未来的探索途径,特别关注肿瘤免疫微环境的潜在进步。
Introduction: Cancer-associated fibroblasts (CAFs) constitute an important component of the tumor microenvironment, participating in various facets of cancer advancement and being recognized as contributors to tumor immune evasion. The role of CAFs in various tumor types has attracted increasing attention recently. In this work, we conducted a comprehensive bibliometric analysis to uncover research trajectories and highlight emerging areas in the field of CAFs. Methods: A systematic search was performed within the Web of Science Core Collection to identify articles/reviews on CAFs published between 2000 and 2023. Leveraging advanced bibliometric tools such as VOSviewer, CiteSpace, and online website, we examined and visualized publication trends, geographic contributions, institutional affiliations, journal prominence, author collaborations, and noteworthy references, keywords, and genes. Results: Our analysis included 5,190 publications, indicating a rapid growth trend in both annual publications and citations related to CAFs. China and the United States emerged as the foremost contributors in terms of publications, funding agencies, and international collaborations. Breast cancer was the most studied tumor, followed by colorectal cancer, pancreatic cancer, prostate cancer, and gastric cancer. Based on co-occurrence and bursting keywords, we identified the following research topics including immune cells (T cells, B-cells, tumor-associated macrophages), tumor immune microenvironment (antitumor immunity, immune infiltration, immunosuppression), immunotherapy (PD-L1), microRNAs (miRNA), extracellular vesicles (exosome), multiple tumors (pancreatic ductal adenocarcinoma, bladder cancer, head and neck squamous cell carcinoma), antitumor agents (gemcitabine, cisplatin resistance), bioinformatics (pan-cancer), epithelial-mesenchymal transition (stemness), FAPI PET/CT, DNA methylation, etc., may receive sustained attention in the future. Furthermore, TGFB1, IL-6, TNF, TP53, and VEGFA emerged as the top 5 genes that have garnered the greatest research attention in the field of CAFs. The KEGG enrichment analysis highlighted that the top 20 most studied genes were mainly associated with HIF-1 and Toll-like receptor signaling pathways. Discussion: In sum, our bibliometric analysis offers a comprehensive overview of the research landscape in the field of CAFs. It encompasses the current state, evolving patterns, and prospective avenues of exploration, with special attention to the potential advancements in tumor immune microenvironment.