背景:我们旨在描述结直肠癌的发病率和死亡率,1982年至2011年马提尼克岛(法属西印度群岛)的时间趋势。
方法:这是一个描述性的,纵向,基于马提尼克岛癌症登记数据的观察性研究。该研究包括1982年至2011年之间的所有结直肠癌事件。我们记录了社会人口统计学数据和临床变量(组织学,根据世界卫生组织分类的网站)。严格按照国际标准记录癌症病例。计算了年变化率,直接标准化用于发病率和死亡率年龄标准化率(ASR).计算比较发病率数字和比较死亡率数字(95%置信区间)。
结果:总计,2530例患者纳入我们的研究;1243例死亡。在2007-2011年期间,观察到发病率大幅增加,使结直肠癌成为男女癌症死亡的第二大原因(8.9%和10.5%)。在男人中,发病率的ASR从1982-1986年的9.6/100,000人年增加到2007-2011年的27.2/100,000人年,增加速度显着加快。在女性中,同期,ASR从8.4增加到19.8/100,000人年。在最近的2007-2011年期间,男性和女性的死亡率分别为9.9和7.6/100,000人年。不管性别,右结肠癌的发病率大幅增加,成为马提尼克岛女性最常见的结直肠部位。
结论:我们的发现证实了从2000年代开始的结直肠癌发病率的增加。观察到的趋势反映了加勒比地区明显的流行病学转变。
BACKGROUND: We aimed to describe incidence and mortality from colorectal cancer, and temporal trends between 1982 and 2011 in Martinique (French West-Indies).
METHODS: This was a descriptive, longitudinal, observational
study based on data from the Martinique cancer registry. The
study included all incident cases of colorectal cancer between 1982 and 2011. We recorded sociodemographic data and clinical variables (histology, site according to the WHO classification). Cancer cases were recorded in strict conformity with the international standards. Annual rate of change was calculated, direct standardisation was used for incidence and mortality age standardised rates (ASR). The comparative incidence figure and comparative mortality figure (95% confidence intervals) were calculated.
RESULTS: In total, 2530 patients were included in our
study; 1243 died. In the period 2007-2011, a considerable increase in incidence was observed, making colorectal cancer the second leading cause of cancer deaths in both sexes (8.9% and 10.5%). In men, ASR for incidence increased from 9.6/100,000 person-years in the period 1982-1986 to 27.2/100,000 person-years in the period 2007-2011, with a notable acceleration of the increase. In women, ASR increased from 8.4 to 19.8/100,000 person-years over the same periods. For the latest period 2007-2011, mortality rates were 9.9 and 7.6/100,000 person-years for men and for women respectively. Regardless of the sex, there was a strong increase in the incidence of right colon cancer, which became the most common colorectal site in women in Martinique.
CONCLUSIONS: Our findings confirm the increase in the incidence of colorectal cancer that started in the 2000s. Trends observed reflect a salient epidemiological transition of the Caribbean.