背景：C1q/TNF相关蛋白9（CTRP9）似乎与2型糖尿病（T2DM）有关，根据日益增长的研究。但是关于T2DM患者CTRP9循环水平的文献一直存在矛盾。
目的：这是一项系统评价和荟萃分析，以重新评估2型糖尿病患者的循环CTRP9水平，有和没有并发症。
方法：直到2021年10月31日发表的相关研究来自PubMed，Embase,WebofScience,科克伦图书馆,万方,CNKI,VIP,和CBM数据库。
方法：年龄≥18岁临床诊断为T2DM的参与者。性别和糖尿病并发症类型不受限制。
方法：数据由2名审阅者使用标准数据收集表独立提取。
结果：分析表明，与无糖尿病患者相比，T2DM患者的CTRP9循环水平显着降低[（SMD=-1.36；95CI（-1.78至-0.93）；P<0.001），I2=97.5%，P<0.001]。此外，T2DM相关并发症患者的循环CTRP9水平低于无并发症的T2DM患者,无论大血管并发症或微血管并发症[(SMD=-1.062;95CI(-1.466至-0.658);P<0.001)，I2=91.3%，P<0.001]。亚组分析显示，体重指数(BMI)等因素，T2DM持续时间,和空腹血糖（FBS）是异质性的来源（分别为P=0.047，P=0.034和P=0.07）。
结论：本系统综述和荟萃分析发现，有或没有并发症的T2DM患者的CTRP9水平较低。然而,因为这是大多数观察性研究的荟萃分析，这些发现仍需要大样本量的进一步研究来验证.
According to growing research, C1q/TNF-Related Protein-9 (
CTRP9) appears to be linked to type 2 diabetes mellitus (T2DM). But the literature on circulating levels of
CTRP9 in patients with T2DM has been contradictory.
This is a systematic
review and meta-analysis to reassess the circulating level of
CTRP9 in patients with T2DM, with and without complications.
Relevant studies published until October 31, 2021, were identified from the PubMed, Embase, Web of Science, Cochrane Library, WanFang, CNKI, VIP, and CBM databases. Participants with age ≥18 years with clinically diagnosed T2DM were included. Sex and diabetes complications were not restricted. The data were extracted by 2 reviewers independently using a standard data collection form.
Analysis demonstrated significantly lower circulating levels of
CTRP9 in patients with T2DM than in patients without diabetes (standardized mean difference [SMD] = -1.36; 95% CI -1.78 to -0.93; P < .001), I2 = 97.5%, P < .001). Furthermore, the circulating level of CTRP9 in patients with T2DM-related complications was lower than that in patients with T2DM without complications, regardless of macrovascular complications or microvascular complications (SMD = -1.062; 95% CI -1.466 to -0.658; P < .001, I2 = 91.3%, P < .001). Subgroup analyses revealed that factors such as body mass index, T2DM duration, and fasting blood glucose were the sources of heterogeneity (P = .047, P = .034, and P = .07, respectively).
The present systematic
review and meta-analysis found
CTRP9 levels were lower in T2DM patients with or without complications. However, since this was a meta-analysis of most observational studies, these findings still need to be verified by further studies with a large sample size.
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