局部紊乱的共生微生物组可能是慢性鼻-鼻窦炎（CRS）的病因，尤其是无鼻息肉（CRSsNP）的CRS。已建议乳酸菌（LAB）恢复共生微生物。已发现由各种乳杆菌和双歧杆菌组成的蜜蜂LAB微生物组在体外对CRS病原体有效。最近,我们检查了这种微生物组的单次鼻腔给药对健康受试者的影响，发现它是惰性的。在这项研究中,我们检查了CRSsNP患者重复此类给药的效果。
这项研究是随机的，双盲,交叉，和假控制设计。
20名患者接受了2周的使用鼻喷雾装置的治疗。对受试者的症状进行了监测(SNOT-22问卷，即，主要功效变量)，微生物组的变化，和炎症产物（IL-6，IL-8，TNF-，IL-8,a,和MPO）在鼻灌洗液中。
两个症状评分，微生物勘探,鼻灌洗液中炎症产物的水平也不受LAB（c.f.sham）的影响。
对CRSsNP患者鼻腔给予蜜蜂LAB微生物组两周的耐受性良好，但既不影响症状严重程度，也不影响微生物区系/局部炎症活动。
1b。
A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (
CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this
study, we examined effects of repeated such administrations in patients with
CRSsNP.
The
study was of a randomized, double-blinded, crossover, and sham-controlled design.
Twenty patients received 2 weeks\' treatment administered using a nasal spray-device. The subjects were monitored with regard to symptoms (SNOT-22 questionnaire, i.e., the primary efficacy variable), changes to their microbiome, and inflammatory products (IL-6, IL-8, TNF-, IL-8,a, and MPO) in nasal lavage fluids.
Neither symptom scores, microbiological explorations, nor levels of inflammatory products in nasal lavage fluids were affected by LAB (c.f. sham).
Two weeks\' nasal administration of a honeybee LAB microbiome to patients with
CRSsNP is well tolerated but affects neither symptom severity nor the microbiological flora/local inflammatory activity.
1b.
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