背景:目前关于claudin-1表达与结直肠癌(CRC)结果相关的报道存在争议。因此,我们进行了一项荟萃分析,以评估claudin-1表达与临床参数之间的相关性,并评估claudin-1在CRC中的预后价值.
方法:PubMed上的系统搜索,Embase,Elsevier,CNKI(中国国家知识基础设施),在2016年8月之前进行了万方数据和Cochrane图书馆。合并比值比(OR)及其95%置信区间(95CI)用于评估claudin-1表达与CRC患者临床参数之间的关联。并评估claudin-1表达与CRC患者预后价值之间的关系。
结果:共纳入8项研究,共1146例CRC患者。总的来说,合并结果显示claudin-1的低表达与CRC患者的TNMIII-IV期相关(OR:1.714,95CI:1.215~2.418,P=0.002).claudin-1的低表达也与CRC患者的低生存率相关(一年生存率:OR:2.112,95CI:1.028-4.339,P=0.042;三年生存率:OR:1.501,95CI:1.030-2.186,P=0.035;五年生存率:OR:1.794,95CI:1.139-2.439,P=0.000)。然而,claudin-1的低表达与性别无关(OR:1.259,95CI:0.957-1.657,P=0.100),肿瘤分化(OR:1.317,95CI:0.916-1.892,P=0.137),CRC的浸润深度(OR:1.016,95CI:0.701-1.472,P=0.935)和淋巴结转移组(OR:1.286,95%CI:0.982-1.684,P=0.06)。
结论:claudin-1的低表达与CRC患者的TNMIII-IV期和不良预后相关。claudin-1的低表达与性别无关,CRC患者的肿瘤分化浸润深度和淋巴结受累。
BACKGROUND: The current reports on the association of claudin-1 expression with colorectal cancer (CRC) result were controversial. Thus, we conducted a meta-analysis to assess the correlation between claudin-1 expression and the clinical parameters and assess the prognostic value of claudin-1 in CRC.
METHODS: Systematic searches on PubMed, Embase, Elsevier, CNKI (China National Knowledge Infrastructure), Wanfang data and Cochrane Library prior to August 2016 were performed. The pooled odds ratio (OR) with its 95% confidence interval (95 %CI) was used to assess association between claudin-1 expression and clinical parameters of CRC patients, and to assess association between claudin-1 expression and the prognostic value of CRC patients.
RESULTS: Eight studies with a total of 1146 CRC patients were included. Overall, the pooled results showed that low expression of claudin-1 was associated with TNM III-IV stage of CRC patients (OR: 1.714, 95%CI: 1.215-2.418, P = 0.002). Low expression of claudin-1 was also associated with a poor survival in CRC patients (one year survival rate: OR: 2.112, 95%CI: 1.028-4.339, P = 0.042; three years survival rate: OR: 1.501, 95%CI: 1.030-2.186, P = 0.035; five years survival rate: OR: 1.794, 95%CI: 1.139-2.439, P = 0.000). Whereas, low expression of claudin-1 is not associated with gender (OR: 1.259, 95%CI: 0.957-1.657, P = 0.100), tumors\' differentiation (OR: 1.317, 95%CI: 0.916-1.892, P = 0.137), depth of invasion (OR: 1.016, 95 %CI: 0.701-1.472, P = 0.935) and lymph node metastasis group (OR: 1.286, 95% CI: 0.982-1.684, P = 0.06) of CRC.
CONCLUSIONS: Low expression of claudin-1 is associated with TNM III-IV stage and poor prognosis of CRC patients. Low expression of claudin-1 is not associated with gender, tumors\' differentiation depth of invasion and lymph node involvement of CRC patients.