背景:颅内动脉瘤通常与炎症相关,是其发展的原因,programming,和破裂。巨噬细胞和其他细胞可以表达CD68抗原。这项研究的目的是评估与伊朗转诊中心对照组相比,脑动脉瘤(CA)患者的CD68抗原水平。
方法:对88名个体进行了病例对照调查(其中44名为病例,44名为对照)。以CA为病例组的个体包括28个破裂亚组和16个未破裂亚组。临床,射线照相,和CD68水平进行评估和登记。
结果:参与者的平均年龄为49岁。男性占患者的43.2%,56.8%为女性(p=0.002)。两组间CD68水平差异有统计学意义。在此比较中,破裂和未破裂亚组(分别为23.66和20.47)之间没有显着差异(p=0.42)。患者的CD68和格拉斯哥昏迷量表(GCS)水平与动脉瘤直径之间没有显着相关性(分别为p=0.74和0.45)。发现了CD68水平和年龄之间的联系,但无统计学意义(r=0.44,p=0.002)。
结论:已提示CD68作为炎症因子可能参与CA的发展,但不参与动脉瘤破裂。炎症和CD68与年龄呈正相关。CD68抗原应在基于人群的队列研究中进一步研究。
BACKGROUND: Intracranial aneurysms are more commonly associated with inflammation as a cause of their development, progression, and rupture. Macrophages and other cells can express the CD68 antigen. The aim of this study was to assess the CD68 antigen levels in cerebral aneurysm (CA) patients compared to a control group at a referral center in Iran.
METHODS: A
case-control investigation was undertaken on 88 individuals (44 of whom were cases and 44 were controls). Individuals with CA as the
case group consisted of 28 ruptured and 16 unruptured subgroups. Clinical, radiographic, and CD68 levels were evaluated and registered.
RESULTS: The average age of the participants was 49 years. Males comprised 43.2% of the patients, while 56.8% were females (p = 0.002). There was a statistically significant difference in the CD68 levels between the two groups. There was no significant difference (p = 0.42) between the ruptured and unruptured subgroups (23.66 and 20.47, respectively) in this comparison. No significant correlation was seen between the patients\' CD68 and Glasgow Coma Scale (GCS) levels and their aneurysm diameter (p = 0.74 and 0.45, respectively). A link between CD68 levels and age was found, but it was not statistically significant (r = 0.44 and p = 0.002).
CONCLUSIONS: A possible involvement of CD68 as an inflammatory agent in the development of CAs but not in aneurysm rupture has been suggested. Inflammation and CD68 were positively associated with age. The CD68 antigen should be studied further in population-based cohort studies.