人akna编码AT-hook转录因子,其表达参与各种细胞过程。我们根据在人类和体内和体外模型中发现的证据,对有关AKNA功能作用的文献进行了范围审查。严格遵循“PRISMA-ScR”声明建议。
我们使用以下搜索词进行了独立的PubMed文献检索:AKNA或AKNAADJ基因或AKNA蛋白,人类或AKNAADJ功能。考虑了观察和实验文章。使用预先确定的数据提取表格对所选择的研究进行分类。产生了证据的叙述性摘要。
AKNA调节免疫系统细胞中CD40和CD40L基因的表达。它是炎症过程的负调节因子,如敲除小鼠模型和几种自身免疫和炎性疾病的观察研究所证明的。此外,AKNA有助于癌症中免疫系统的去调节,它已被提议作为CC的易感遗传因素和生物标志物,GC,和HNSCC。最后,AKNA通过使微管动力学不稳定来调节神经发生。
我们的结果为AKNA在各种细胞过程中的作用提供了证据,包括免疫反应,炎症,发展,癌症,自身免疫,和神经发生。
Human akna encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping
review on the literature regarding the functional role of AKNA according to the evidence found in human and in vivo and in vitro models, stringently following the \"PRISMA-ScR\" statement recommendations.
We undertook an independent PubMed literature search using the following search terms, AKNA OR AKNA ADJ gene OR AKNA protein, human OR AKNA ADJ functions. Observational and experimental articles were considered. The selected studies were categorized using a pre-determined data extraction form. A narrative summary of the evidence was produced.
AKNA modulates the expression of CD40 and CD40L genes in immune system cells. It is a negative regulator of inflammatory processes as evidenced by knockout mouse models and observational studies for several autoimmune and inflammatory diseases. Furthermore, AKNA contributes to the de-regulation of the immune system in cancer, and it has been proposed as a susceptibility genetic factor and biomarker in CC, GC, and HNSCC. Finally, AKNA regulates neurogenesis by destabilizing the microtubules dynamics.
Our results provide evidence for the role of AKNA in various cellular processes, including immune response, inflammation, development, cancer, autoimmunity, and neurogenesis.