趋化因子是一组具有低分子量的细胞因子,其主要指导靶细胞的趋化性。它们在系统性红斑狼疮(SLE)和相关并发症特别是狼疮性肾炎的发病机理中具有重要作用。这些分子不仅在患者的器官中诱导自身免疫反应,而且还可以放大诱导的炎症反应。虽然趋化因子家族至少有46个确定的成员,在SLE患者或该疾病的动物模型中,许多这些分子的作用已得到更多阐明。在当前的论文中,我们综述了CCL2、CCL3、CCL4、CCL11、CCL20、CXCL1、CXCL2、CXCL8、CXCL10、CXCL12和CXCL13在SLE发病机制中的作用。
Chemokines are a group of cytokines with low molecular weight that principally direct chemotaxis of target cells. They have prominent roles in the pathogenesis systemic lupus erythematosus (SLE) and related complications particularly lupus nephritis. These molecules not only induce autoimmune responses in the organs of patients, but also can amplify the induced inflammatory responses. Although chemokine family has at least 46 identified members, the role of a number of these molecules have been more clarified in SLE patients or animal models of this disorder. In the current paper, we
review the role of CCL2, CCL3, CCL4, CCL11,
CCL20, CXCL1, CXCL2, CXCL8, CXCL10, CXCL12 and CXCL13 in the pathogenesis of SLE.