认知功能障碍在老年人中很常见,特别是那些2型糖尿病(T2D)。对美国人饮食指南的更高依从性与更好的大脑健康有关。然而,目前尚不清楚遵守澳大利亚膳食指南(ADG)是否与老年人的认知或大脑结构相关.
这项研究的目的是1)检查坚持ADG之间的关系,认知,和脑部MRI,以及2)确定T2D是否修饰任何关联。
塔斯马尼亚老年人的认知和糖尿病研究是一项对688名55-90岁人群(n=343名T2D患者)的横断面研究。使用经过验证的80项食物频率问卷来评估饮食摄入量。使用饮食指南指数(DGI)估计对2013年ADG的依从性。通过全面的神经心理学测试和MRI脑结构评估了多个领域的认知功能。多变量线性模型用于评估DGI,认知z分数,和大脑结构。用DGI×T2D产品术语检查T2D的效果变化。
样本的平均年龄为69.9y(SD:7.4y),男性占57.1%。平均DGI为54.8(SD:10.7;范围:24.1-84.6)。未观察到澳大利亚DGI与认知或脑部MRI测量之间的关联。T2D没有改变任何关联(P>0.05)。
这是第一项调查有和没有T2D的老年人对ADG的依从性与大脑健康之间关系的研究。未来的前瞻性研究需要澄清是否存在长期关联。
Cognitive dysfunction is common in older adults, particularly in those with type 2 diabetes (T2D). Higher adherence to the Dietary
Guidelines for Americans is associated with better brain health. However, it is unclear if adherence to the Australian Dietary
Guidelines (ADG) is associated with cognition or brain structure in older adults.
The aims of this study were to 1) examine the relation between adherence to the ADG, cognition, and brain MRI and 2) determine whether T2D modifies any associations.
The Cognition and Diabetes in Older Tasmanians Study is a cross-sectional study in 688 people (n = 343 with T2D) aged 55-90 y. A validated 80-item food-frequency questionnaire was used to assess dietary intake. Adherence to the 2013 ADG was estimated using the Dietary
Guidelines Index (DGI). Cognitive function in multiple domains was assessed with a comprehensive battery of neuropsychological tests and brain structure with MRI. Multivariable linear models were used to assess the associations between DGI, cognitive z scores, and brain structure. Effect modification for T2D was examined with a DGI × T2D product term.
The mean age of the sample was 69.9 y (SD: 7.4 y), with 57.1% men. The mean DGI was 54.8 (SD: 10.7; range: 24.1-84.6). No associations were observed between the Australian DGI and cognition or brain MRI measures. T2D did not modify any associations (P > 0.05).
This is the first study to investigate associations between adherence to the ADG and brain health in the older adults with and without T2D. Future prospective studies are required to clarify if there are long-term associations.