背景:阴茎转移是极为罕见的事件,主要起源于前列腺的原发性盆腔肿瘤,膀胱,和胃肠道。膀胱癌转移到阴茎的潜在机制尚不清楚。阴茎转移通常被认为是全身扩散的晚期表现。因此,阴茎转移患者预后差,生存期短。因此,报告这一罕见病例将有助于更好地理解其特征,诊断,以及疾病的治疗过程,目的是提高诊断和治疗的准确性和效率。
方法:一名65岁男性患者接受经尿道膀胱肿瘤切除术。一年后,由于膀胱癌的复发和进展,他接受了根治性膀胱切除术。术后病理证明膀胱癌分期为T3N0M0。一年后,他发现了一个逐渐长大并变硬的阴茎团,伴有尿潴留,但没有其他临床症状.患者接受了完整的阴茎切除术。组织病理学和免疫组织化学结果表明肿瘤起源于膀胱尿路上皮癌。患者术后接受全身化疗,但7个月后死亡。
结论:尽管膀胱癌的阴茎转移通常表明恶性肿瘤的晚期和不良预后,我们建议有膀胱癌病史的男性患者应定期对阴茎进行临床检查,以迅速发现疾病并接受早期治疗。在这种情况下,尽管采取了全身化疗和阴茎切除术等治疗措施,患者的预后仍然较差。
BACKGROUND: Penile metastases are extremely rare events, originating primarily from primary pelvic tumours of the prostate, bladder, and gastrointestinal tract. The underlying mechanism of bladder cancer metastasis to the penis remains unclear. Metastasis to the penis is usually considered a late manifestation of systemic spread. Therefore, the prognosis of patients with penile metastasis remains poor and their survival period is short. Therefore, reporting this rare
case will help to better understand the characteristics, diagnosis, and treatment processes of the disease, with the aim of improving the accuracy and efficiency of diagnosis and treatment.
METHODS: A 65-year-old male received transurethral resection of a bladder tumor. One year later, he underwent radical cystectomy because of the recurrence and progression of bladder cancer. Postoperative pathology demonstrated that the stage of bladder cancer was T3N0M0. One year later, he discovered a penile mass that gradually grew and became hard, accompanied by urinary retention, but without other clinical symptoms. The patient underwent a complete penectomy. Histopathology and immunohistochemistry results demonstrated the tumour\'s origin as a bladder urothelial carcinoma. The patient received systemic chemotherapy after surgery, but died 7 months later.
CONCLUSIONS: Although penile metastasis of bladder cancer typically indicates an advanced stage of the malignant tumour and poor prognosis, we recommend that male patients with a history of bladder cancer should undergo a regular clinical examination of the penis to rapidly detect the disease and receive early treatment. In this
case, despite treatment measures such as systemic chemotherapy and penectomy, the patient\'s prognosis remained poor.