背景:胆囊癌(GBC)和胆管癌是在与肝脏相关的胆囊和胆道中发展的侵袭性癌症形式。这篇系统的综述旨在强调胆囊之间的显著关联,胆道癌,和砷暴露。
方法:在Embase进行了广泛的搜索,科克伦,Scopus,PubMed,和WebofScience。我们纳入了评估胆囊癌患者砷水平的研究,没有年龄限制,性别,或语言。生物样本,这样的血,胆汁,胆囊组织,胆结石,获得了头发,并测定了砷的含量。此外,收集砷水和土壤浓度。
结果:共有13项研究纳入我们的综述。这些研究包括2234例非胆囊癌患者和22585例胆囊癌患者。参与者的人口统计数据显示862名男性和1845名女性的性别分布,年龄范围为20-75岁。非膀胱癌患者的平均体重指数(BMI)为19.8kg/m2,胆囊癌患者的平均体重指数为20.1kg/m2。选定的研究检查了各种生物样品中的砷浓度,包括血,头发,胆结石,还有胆汁.在几项研究中,血砷水平为0.0002至0.3893μg/g,与胆囊癌风险增加显着相关。头发也表现出显著的相关性,砷浓度范围为0.0002至6.9801μg/g。
结论:砷暴露与胆囊癌或胆管癌之间有很强的联系。即使长期暴露于低-中度量也可能导致胆囊癌。这些发现强调需要更全面和专注的研究,以控制水/土壤中的砷含量,并寻求针对这种高死亡率疾病的其他预防措施。
BACKGROUND: Gallbladder carcinoma (GBC) and cholangiocarcinoma are aggressive forms of cancer developed in the gallbladder and biliary tracts which are related to the liver. This systematic
review aimed to highlight the significant association between gallbladder, biliary cancers, and arsenic exposure.
METHODS: An extensive search was conducted in Embase, Cochrane, Scopus, PubMed, and Web of Science. We included studies that assessed arsenic levels in gallbladder cancer patients, without restrictions on age, sex, or language. Biological samples, such blood, bile, gallbladder tissue, gallstones, and hair were obtained, and arsenic levels were measured. Also, arsenic water and soil concentrations were collected.
RESULTS: A total of 13 studies were included in our
review. These studies included 2234 non-gallbladder carcinoma patients and 22 585 gallbladder carcinoma cases. The participant demographics showed a gender distribution of 862 males and 1845 females, with an age range of 20-75 years. The average body mass index (BMI) was 19.8 kg/m2 for nongallbladder carcinoma patients and 20.1 kg/m2 for gallbladder carcinoma cases. The selected studies examined arsenic concentrations across various biological samples, including blood, hair, gallstones, and bile. Blood arsenic levels ranged from 0.0002 to 0.3893 μg/g and were significantly associated with increased gallbladder carcinoma risk in several studies. Hair also demonstrated a significant correlation, with arsenic concentrations ranging from 0.0002 to 6.9801 μg/g.
CONCLUSIONS: There is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low-moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water/soil levels and seek other preventive measures for this high mortality disease.