目的：复发性流产是目前的咨询模式。病因学评估是经典的建议，应讨论预防性治疗。我们想研究我们大学医院的妊娠结局，在3次重复的早期流产之后，以及如何管理这些患者。
方法：我们中心进行了为期10年的回顾性研究，296名患者发现有三次重复流产经历。有关流产后诊断评估的信息，预防性治疗开始，并提供了下一次妊娠结局。
结果：大约62.5%的患者经历了终身分娩。当调查完成时(n=148)，64.9%的患者有异常结果.当存在正常核型或未发现血栓形成倾向（分别为p等于0.30和0.45）时，寿命出生率更为重要。我们注意到，在接受预防性治疗的正常调查结果的患者组中，预后较好（n=20，85％的终身出生，P=0.19）。
结论：完成后，经常流产的调查，允许在三分之二的病例中发现异常。令人惊奇的是,结果非常令人鼓舞,因为近三分之二的患者经历了终身分娩.调查迹象,结果解释，和连续治疗应该是深思熟虑的，但预防性治疗在正常结果的患者组中似乎是有效的。
OBJECTIVE: Recurrent miscarriages are a current consultation pattern. Etiologic evaluation is classically proposed and preventive therapy should be discussed. We wanted to
study our University Hospital pregnancies outcomes, following 3 repetitive early miscarriages, and how those patients are managed.
METHODS: A 10-years retrospective
study has been performed in our center, with 296 patients found having a three-repetitive miscarriage experience. Information about diagnostic evaluation following miscarriages, preventive therapy initiation, and next pregnancy outcome has been provided.
RESULTS: Around 62.5% of the patients experienced a life-birth. When investigations were done (n=148), a 64.9% part of the patients had abnormal results. Life-birth rate was more important when there were normal karyotypes or no thrombophilia found (respectively p equal 0.30 and 0.45). We noticed a better prognostic in the group of patients with normal investigations results who had a preventive therapy (n=20, 85% of life-birth, P=0.19).
CONCLUSIONS: When done, investigations for recurrent miscarriages, allow the finding of an abnormality in two thirds of cases. Wonderingly, outcomes are very encouraging since that almost two thirds of the patients experienced life-birth. Investigations indications, results interpretations, and consecutive therapy should be well thought but preventive therapy seems to be efficient in the normal results patient group.
PDF(Sci-hub)