背景:为探讨中国东营地区局部过敏性疾病患者对花粉和食物过敏原的特异性免疫球蛋白E水平之间的关系,并分析这些因素之间的相互联系。
方法:本研究对象为2022年1月至2023年1月到胜利油田中心医院变态反应科就诊的过敏患者。我们利用江苏豪博公司提供的Fobock平台检测了230例患者血液中的特异性免疫球蛋白E水平。采用SPSS25.0统计软件进行统计学分析。卡方检验评估了性别和年龄差异的相关性。P<0.05的值被认为具有统计学意义。
结果:在这项研究中,卵子是致敏个体数量最多的过敏原,紧随其后的是尘螨。相反,最不敏感的过敏原是柏树,紧随其后的是芒果。值得注意的是,与女性患者相比,男性患者对杨木(P<.05)和卵(P<.001)的敏感性更高。0至10岁的儿童对各种过敏原的敏感性增加。在不同的过敏原之间观察到显著的相关性。相关性最高的前十对过敏原包括桦树和杨木(0.88,P<.001),杨木和松树(0.86,P<.001),桦树和松树(0.84,P<.001),松树和泡桐(0.81,P<.001),尘螨和屋尘螨(0.76,P<.001),桦树和泡桐(0.73,P<.001),腰果和开心果(0.71,P<.001),苹果和榛子(0.71,P<.001),杨木和泡桐(0.71,P<.001),和松树和普通紫草(0.70,P<.001)。
结论:这项研究揭示了东营市过敏原致敏的模式,山东,强调鸡蛋是最普遍的致敏过敏原。在桦树和杨木之间观察到了非常高的相关性。这项研究提高了人们对过敏性疾病的认识,探索过敏的原因和机制,加强对过敏性疾病的管理。此外,它为临床诊断和预防过敏性疾病提供了有价值的见解。
BACKGROUND: To explore the relationship between specific immunoglobulin E levels in response to prevalent pollen and food allergens among patients suffering from localized allergic diseases in the Dongying area of China, and to analyze the interconnectivity among these factors.
METHODS: This research encompassed allergic patients who visited the Allergy Department of Shengli Oilfield Central Hospital from January 2022 to January 2023. We examined the specific immunoglobulin E levels in the blood of 230 patients utilizing the Fobock platform provided by Jiangsu Haoeubo Company. Statistical analysis was conducted with SPSS 25.0 statistical software. The chi-square test evaluated the relevance of differences in gender and age. A value of P < .05 was considered statistically significant.
RESULTS: In this
study, eggs emerged as the allergen with the highest number of sensitized individuals, closely followed by dust mite. Conversely, the least sensitized allergen was the cypress tree, closely followed by mango. Notably, male patients exhibited higher sensitivities to cottonwood (P < .05) and egg (P < .001) compared to female patients. Children aged 0 to 10 years showed increased sensitivity to variety of allergens. A significant correlation was observed among different allergens. The top ten allergen pairs with the highest correlation included Birch Tree and Cottonwood (0.88, P < .001), Cottonwood and Pine Tree (0.86, P < .001), Birch Tree and Pine Tree (0.84, P < .001), Pine Tree and Paulownia (0.81, P < .001), Dust Mite and House Dust Mite (0.76, P < .001), Birch Tree and Paulownia (0.73, P < .001), Cashew and Pistachio (0.71, P < .001), Apple and Hazelnut (0.71, P < .001), Cottonwood and Paulownia (0.71, P < .001), and Pine Tree and Ordinary Ragweed (0.70, P < .001).
CONCLUSIONS: This research sheds light on the patterns of allergen sensitization in Dongying, Shandong, highlighting that egg is the most prevalent sensitizing allergen. A notably high correlation was observed between Birch Tree and Cottonwood. This
study enhanced the understanding of allergic diseases, explored the causes and mechanisms of allergies, strengthened the management of allergic diseases. Furthermore, it offers valuable insights for the clinical diagnosis and prevention of allergic diseases.