gibsoni巴贝斯虫在全球范围内越来越被认为是犬蜱传贫血的原因;然而,只有少数自然获得性感染的临床报告可用。在这项系统的研究中,研究犬出现了双歧杆菌感染,我们收集了2014年1月至2015年12月台湾大学兽医教学医院(NTUVH)收治的经PCR证实的双歧杆菌感染犬的临床和实验室数据.在招募的60只狗中,20例(33.3%)并发疾病,40例(66.7%)仅感染了吉布氏芽孢杆菌。同时或不同时感染的B.gibsoni感染犬的贫血严重程度没有显着差异。最常见的血液学异常是贫血(49/60,81.7%)和血小板减少(37/60,61.7%)。49只狗中,24(49%)患有严重至非常严重的贫血(PCV<20%)。主要生化异常包括高球蛋白血症(28/53,52.8%),高胆红素血症(10/28,35.7%)和肝酶活性升高(7/48,14.6%)。此外,60只客户拥有的狗中的2只和33只B.gibsoni阳性流浪狗中的5只被检测为具有天然抗atovaquone菌株,使用SimpleProbe®测定。该研究结果提供了B.gibsoni感染的有用临床表现,并提出了台湾目前存在的天然抗atovaquone菌株的问题。
Babesia gibsoni is increasingly recognized globally as a cause of canine tick-borne anemic disease; however, only a few clinical reports of naturally acquired infection are available. In this systematic
study of dogs presenting with B. gibsoni infection, clinical and laboratory data were collected for dogs with PCR-confirmed B. gibsoni infection admitted to the National Taiwan University Veterinary Teaching Hospital (NTUVH) from January 2014 through December 2015. Of the 60 dogs recruited, 20 (33.3%) had concurrent disease and 40 (66.7%) had only B. gibsoni infection. The severity of anemia in B. gibsoni infected dogs with concurrent or without concurrent infection was not significantly different. The most commonly observed hematological abnormalities were anemia (49/60, 81.7%) and thrombocytopenia (37/60, 61.7%). Of 49 dogs, 24 (49%) had severe to very severe anemia (PCV < 20%). The main biochemical abnormalities included hyperglobulinemia (28/53, 52.8%), hyperbilirubinemia (10/28, 35.7%) and elevated hepatic enzyme activity (7/48, 14.6%). In addition, 2 of the 60 the client-owned dogs and 5 of the 33 B. gibsoni-positive stray dogs were detected as having a naturally atovaquone-resistant strain, using the SimpleProbe® assay. The
study results provide a useful clinical presentation of B. gibsoni infection and raise the issue of the naturally atovaquone-resistant strain currently existing in Taiwan.